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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ass spectrometry applied to diagnosis, prognosis, and therapeutic targets identification for the novel coronavirus SARS-CoV-2: A revie

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Author(s):
Lima, Nerilson M. [1] ; Fernandes, Bruno L. M. [1] ; Alves, Guilherme F. [1] ; de Souza, Jessica C. Q. [1] ; Siqueira, Marcelo M. [1] ; do Nascimento, Maria Patricia [1] ; Moreira, Olivia B. O. [1] ; Sussulini, Alessandra [2, 3] ; de Oliveira, Marcone A. L. [1, 3]
Total Authors: 9
Affiliation:
[1] Univ Fed Juiz de Fora, Inst Exact Sci, Chem Dept, BR-36026900 Juiz De Fora, MG - Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOm, POB 6154, BR-13083970 Campinas, SP - Brazil
[3] Univ Campinas UNICAMP, Inst Chem, Natl Inst Sci & Technol Bioanalyt INCTBio, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Analytica Chimica Acta; v. 1195, FEB 22 2022.
Web of Science Citations: 0
Abstract

Mass spectrometry (MS) has found numerous applications in medicine and has been widely used in the detection and characterization of biomolecules associated with viral infections such as COVID-19. COVID19 is a multisystem disease and, therefore, the need arises to carry out a careful and conclusive assessment of the pathophysiological parameters involved in the infection, to develop an effective therapeutic approach, assess the prognosis of the disease, and especially the early diagnosis of the infected population. Thus, the urgent need for highly accurate methods of diagnosis and prognosis of this infection presents new challenges for the development of laboratory medicine, whose methods require sensitivity, speed, and accuracy of the techniques for analyzing the biological markers involved in the infection. In this context, MS stands out as a robust analytical tool, with high sensitivity and selectivity, accuracy, low turnaround time, and versatility for the analysis of biological samples. However, it has not yet been adopted as a frontline clinical laboratory technique. Therefore, this review explores the potential and trends of current MS methods and their contribution to the development of new strategies to COVID-19 diagnosis and prognosis and how this tool can assist in the discovery of new therapeutic targets, in addition, to comment what could be the future of MS in medicine. (c) 2021 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Marco Aurelio Zezzi Arruda
Support Opportunities: Research Projects - Thematic Grants