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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

osterior segment findings by spectral-domain optical coherence tomography and clinical associations in active toxoplasmic retinochoroiditi

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Author(s):
Oliver, Genevieve F. [1, 2] ; Ferreira, Lisia Barros [2] ; Vieira, Barbara R. [1] ; Arruda, Sigrid [1] ; Araujo, Michelle [1] ; Carr, Jillian M. [2] ; Smith, Justine R. [2] ; Furtado, Joao M. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Ophthalmol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA - Australia
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 12, n. 1 JAN 21 2022.
Web of Science Citations: 0
Abstract

Toxoplasmic retinochoroiditis is a common, potentially blinding parasitic infection. We sought to define the spectrum and frequency of signs of active toxoplasmic retinochoroiditis by spectral domain optical coherence tomography (SD-OCT), and to identify clinical associations. Ninety eyes of 90 individuals presenting consecutively to a tertiary referral uveitis service with active toxoplasmic retinochoroiditis and gradable SD-OCT scans were evaluated prospectively. SD-OCT features were collated, and associations with lesion location, primary versus recurrent episode, serological status, human immunodeficiency virus infection and best-corrected Snellen visual acuity were explored. Active toxoplasmic retinochoroiditis presented with thickened (65%) and hyperreflective (61%) retina, choroidal thickening (55%) and hyporeflectivity (61%), hyperreflective vitreous dots (80%) and deposits (36%), and posterior hyaloid thickening (35%) on SD-OCT. Most signs occurred with similar frequency across clinical groups. Retinal hyporeflectivity (17%) was significantly associated with a visual acuity of 20/200 or worse at resolution. Our observations demonstrate that active toxoplasmic retinochoroiditis has diverse SD-OCT signs and that none are universally present. Retinal hyporeflectivity-suggesting liquefactive necrosis-predicts poor visual outcome. (AU)

FAPESP's process: 17/06680-4 - Occurrence of blindness and visual impairment in patients with ocular toxoplasmosis followed at the Hospital das Clínicas of the Medical School of Ribeirão Preto, University of São Paulo (HCFMRP-USP)
Grantee:Michelle Rodrigues Araujo
Support Opportunities: Scholarships in Brazil - Scientific Initiation