| Full text | |
| Author(s): |
Polho, Gabriel B.
[1]
;
Cardillo, Giancarlo M.
[1]
;
Kerr, Daniel S.
[1]
;
Chile, Thais
[2]
;
Gattaz, Wagner F.
[1]
;
Forlenza, Orestes V.
[1]
;
Brentani, Helena P.
[2]
;
De-Paula, Vanessa J.
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Dept Inst & Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Hosp Clin HCFMUSP, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept Inst & Psiquiatria, Lab Psicobiol LIM-23, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | NEURAL REGENERATION RESEARCH; v. 17, n. 5, p. 1156-1160, MAY 2022. |
| Web of Science Citations: | 0 |
| Abstract | |
Antipsychotics may prolong or retain telomere length, affect mitochondrial function, and then affect the metabolism of nerve cells. To validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury, leukocytes from healthy volunteers were extracted using Ficoll-Histopaque density gradient. The mononuclear cells layer was resuspended in cell culture medium. Oxidative stress was induced with hydrogen peroxide in cultured leukocytes. Four days later, leukocytes were treated with aripiprazole, haloperidol or clozapine for 7 days. Real-time PCR revealed that treatments with aripiprazole and haloperidol increased the telomere length by 23% and 20% in peripheral blood mononuclear cells after acute oxidative stress injury. These results suggest that haloperidol and aripiprazole can reduce the damage to telomeres induced by oxidative stress. (AU) | |
| FAPESP's process: | 16/01302-9 - Direct and indirect pathways of glycogen synthase kinase 3B inhibition by lithium in culture of neurons |
| Grantee: | Vanessa de Jesus Rodrigues de Paula |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/27129-6 - Study of antipsychotic effects on telomere length |
| Grantee: | Gabriel Berlingieri Polho |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |