MPA and angiotensin type 1 receptors are necessary for hemorrhage-induced vasopressin secretio

Author(s)

Dos-Santos, R. C. ^{[1, 2]} ; Vilhena-Franco, T. ^[2] ; Reis, L. C. ^[1] ; Elias, L. L. K. ^[2] ; Antunes-Rodrigues, J. ^[2] ; Mecawi, A. S. ^[3]

Affiliation

^[1] Univ Fed Rural Rio de Janeiro, Dept Ciencias Fisiol, Seropedica, RJ - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, Ribeirao Preto, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biofis, Lab Neuroendocrinol, Escola Paulista Med, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 55, n. 1 2022.
• Web of Science Citations: 0

Abstract

Hypovolemia induced by hemorrhage is a common clinical complication, which stimulates vasopressin (AVP) secretion by the neurohypophysis in order to retain body water and maintain blood pressure. To evaluate the role of brain L-glutamate and angiotensin II on AVP secretion induced by hypovolemia we induced hemorrhage (similar to 25% of blood volume) after intracerebroventricular (icy) administration of AP5, NBQX, or losartan, which are NMDA, AMPA, and All receptor antagonists, respectively. Hemorrhage significantly increased plasma AVP levels in all groups. The icy injection of AP5 did not change AVP secretion in response to hemorrhage. Conversely, icy administration of both NBQX and losartan significantly decreased plasma AVP levels after hemorrhage. Therefore, the blockade of AMPA and All receptors impaired AVP secretion in response to hemorrhage, suggesting that L-glutamate and angiotensin II acted in these receptors to increase AVP secretion in response to hemorrhage-induced hypovolemia. (AU)

• FAPESP's process: 19/01260-2 - The role of hypothalamic paraventricular nucleus GABAergic and CRHergic neurons on ghrelin's effect on energy metabolism
• Grantee: Raoni da Conceição dos Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral