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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

mega-3 Fatty Acid Supplementation and Its Impact on Systemic Inflammation and Body Weight in Patients With Cancer Cachexia-A Systematic Review and Meta-Analysi

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Author(s):
de Castro, Gabriela Salim [1, 2] ; Andrade, Marcia Fabia [1, 2] ; Pinto, Flaydson Clayton Silva [2] ; Faiad, Jaline Zandonato [2] ; Seelaender, Marilia [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Dept Biol Celular & Desenvolvimento, Inst Ciencias Biomed, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, LIM 26 HC, Dept Cirurgia, Canc Metab Res Grp, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN NUTRITION; v. 8, JAN 31 2022.
Web of Science Citations: 0
Abstract

Body weight loss and inflammation are major alterations related to cancer cachexia, an important wasting syndrome highly prevalent in many types of cancer. Nutritional components modulate inflammation in several chronic diseases. Omega-3 fatty acids (n-3) are well known for their anti-inflammatory properties. However, the effects of n-3 on cancer cachexia are still controversial. This systematic review and meta-analysis aims to evaluate the reported effects of n-3 supplementation on body weight and inflammatory markers in patients with cancer cachexia. Articles indexed in the major scientific platforms were retrieved in agreement with the Preferring Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and 167 references were initially found. After removing duplicates and applying the inclusion and exclusion criteria, this systematic review included six studies. Using a random-effects model with 95% CI, three effect sizes were expressed as standard mean difference (SMD). No differences were found regarding the effect of n-3 on interleukin-6, C-reactive protein, and albumin levels. Body weight analysis included only two studies, devoid of robust conclusions. The low number of studies, low sample size, and great intra-variability precluded a stronger analysis. More studies evaluating n-3 supplementation in cancer cachexia are still needed. (AU)

FAPESP's process: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach
Grantee:Marilia Cerqueira Leite Seelaender
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/07765-6 - Adipose tissue contribution to the citokine storm of COVID 19 patients
Grantee:Marilia Cerqueira Leite Seelaender
Support Opportunities: Regular Research Grants