| Full text | |
| Author(s): Show less - |
J. Chinoca
[1]
;
D.S. Andrade
[2]
;
A. Mendes
[3]
;
P. De Marchi
[4]
;
T.G. Prieto
[5]
;
C.M. Baldavira
[6]
;
C. Farhat
[7]
;
J.R.M. Martins
;
H.B. Nader
[9]
;
D.M. Carraro
[10]
;
V.L. Capelozzi
[11]
;
V. de Sá
Total Authors: 12
|
| Affiliation: Show less - | [1] AC Camargo Cancer Center. Laboratório de Genômica e Biologia Molecular - Brasil
[2] AC Camargo Cancer Center. Laboratório de Genômica e Biologia Molecular - Brasil
[3] Universidade Federal de São Paulo. Disciplina de Biologia Molecular, Escola Paulista de Medicina. Departamento de Bioquímica - Brasil
[4] Hospital de Amor de Barretos. Departamento de Oncologia Médica - Brasil
[5] Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia - Brasil
[7] Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia - Brasil
[9] Universidade Federal de São Paulo. Disciplina de Biologia Molecular, Escola Paulista de Medicina. Departamento de Bioquímica - Brasil
[10] AC Camargo Cancer Center. Laboratório de Genômica e Biologia Molecular - Brasil
[11] Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia - Brasil
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Medical and Biological Research; v. 55, 2022-01-25. |
| Abstract | |
We evaluated whether hyaluronan (HA) levels in the sputum could be used as a noninvasive tool to predict progressive disease and treatment response, as detected in a computed tomography scan in non-small cell lung cancer (NSCLC) patients. Sputum samples were collected from 84 patients with histological confirmation of NSCLC, 33 of which were in early-stage and 51 in advanced-stage disease. Patients received systemic chemotherapy (CT) after surgery (n=36), combined CT and immunotherapy (IO) (n=15), or targeted therapy for driver mutation and disease relapse (N=4). The primary end-point was to compare sputum HA levels in two different concentrations of hypertonic saline solution with overall survival (OS) and the secondary and exploratory end-points were radiologic responses to treatment and patient outcome. Higher concentrations of HA in the sputum were significantly associated to factors related to tumor stage, phenotype, response to treatment, and outcome. In the early stage, patients with lower sputum HA levels before treatment achieved a complete tumor response after systemic CT with better progression-free survival (PFS) than those with high HA levels. We also examined the importance of the sputum HA concentration and tumor response in the 51 patients who developed metastatic disease and received CT+IO. Patients with low levels of sputum HA showed a complete tumor response in the computed tomography scan and stable disease after CT+IO treatment, as well as a better PFS than those receiving CT alone. HA levels in sputum of NSCLC patients may serve as a candidate biomarker to detect progressive disease and monitor treatment response in computed tomography scans. (AU) | |
| FAPESP's process: | 18/20403-6 - Biomolecular markers of proliferation and remodeling in acute and chronic respiratory diseases: promising therapeutic targets |
| Grantee: | Vera Luiza Capelozzi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/26642-4 - Detection of hyaluronan and mutations in sputum liquid biopsy as screening in patient with lung cancer |
| Grantee: | Vanessa Karen de Sá |
| Support Opportunities: | Research Grants - Young Investigators Grants |