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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?

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Author(s):
Vânia Belintani PIATTO [1] ; Danielle Lopes Teixeira FERDINANDO [2] ; Hamilton Luiz Xavier FUNES [3]
Total Authors: 3
Affiliation:
[1] Faculty of Medicine, São Jose do Rio Preto. Department of Anatomy - Brasil
[2] Faculty of Medicine, São José do Rio Preto. Department of Pediatrics and Pediatrics Surgery - Brasil
[3] Faculty of Medicine, São Jose do Rio Preto. Department of Anatomy - Brasil
Total Affiliations: 3
Document type: Journal article
Source: ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY; v. 35, 2022-06-17.
Abstract

ABSTRACT - BACKGROUND: After bariatric surgery, if there is iron-refractory iron-deficiency anemia (IRIDA) and does not respond to supplemental iron therapy, excluding other possible etiologies, genetic changes involved in iron metabolism should be considered. AIM: This study aimed to investigate the association of both mutations 1285G-C and 1246C-T, in the SLC11A2 gene, and the etiopathogenesis of anemia refractory to iron supplementation in patients undergoing bariatric surgery using Roux-en-Y gastric bypass (RYGB). METHODS: A case-control study was conducted, in which 100 patients were evaluated as Cases Group [subdivided into (i) with Anemia and (ii) without Anemia] and 100 individuals as Controls, comprising both sexes. Inherited and acquired causes of IRIDA were excluded. DNA was extracted from leukocytes of peripheral blood, and the regions that cover both mutations have been amplified by the molecular techniques such as polymerase chain reaction/restriction fragment length polymorphism. RESULTS: The 1285G-C mutation was not determined in any of the 400 alleles analyzed. Regarding the 1246C-T mutation, the wild CC genotype was found with a higher prevalence in the Control Group (34%) (OR 0.5475; 95%CI 0.2920-1.027; p=0.0827). The mutant TT genotype was found only in the Cases Group I (with Anemia) (13%). CONCLUSION: The results show the association between 1246C-T mutation, in the SLC11A2 gene, and the etiopathogenesis of IRIDA to iron supplementation in the evaluated sample. There are differences, at the molecular level, in patients with and without IRIDA after bariatric surgery using RYGB. (AU)

FAPESP's process: 18/22750-5 - Refractory and persistent iron deficiency anemia after bariatric surgery: investigation of both mutations 1285g-c and 1246c-t in the SLC11A2 gene
Grantee:Vânia Belintani Piatto
Support Opportunities: Regular Research Grants