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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome

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Author(s):
Eloiza de Oliveira Silva [1] ; Carolina Conde [2] ; Douglas Ikedo Machado [3] ; Sara Ventura [4] ; Sheila Marques Fernandes Couto [5] ; Maria de Fátima Fernandes Vattimo [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
[2] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
[3] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
[4] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
[5] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
[6] Universidade de São Paulo. Escola de Enfermagem. Laboratório Experimental de Modelos Animais - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Revista da Escola de Enfermagem da USP; v. 56, 2022-06-29.
Abstract

ABSTRACT Objective: To evaluate the effect of curcumin on renal function, hemodynamics, and renal oxidative profile of rats with chronic kidney disease (CKD) subjected to renal ischemia-reperfusion injury (IRI). Methods: Wistar rats, 250–300 g, distributed in four groups: Sham (n = 5), CKD simulation; CKD (n = 5), 5/6 renal ablation for CKD induction; CKD + IRI (n = 5), CKD and renal pedicle clamping for 30 minutes; and CKD + IRI+curcumin (n = 5), CKD + IRI, curcumin administration 30 mg/kg/day, orally, for 10 days. Renal function (inulin clearance, urine flow, plasma creatinine), hemodynamics (blood pressure), and oxidative profile (peroxides, TBARS, and urine nitrate, non-protein soluble thiols in renal tissue) were evaluated. Results: The CKD + IRI + curcumin group showed increased inulin clearance and reduced plasma creatinine, decreased RVR and increased RBF, decreased oxidative metabolites in urine and increased thiols in renal tissue when compared with the CKD + IRI group. Conclusion: The treatment with curcumin preserved renal function and hemodynamics of animals with acute CKD, improving oxidative profile, with reduction of oxidants and preservation of antioxidant reserve. (AU)

FAPESP's process: 14/22551-1 - The role of the coenzyme Q10 in the iodinated contrast nephropaty in diabetic rats
Grantee:Sheila Marques Fernandes
Support Opportunities: Scholarships in Brazil - Master