Bronsted Acid Mediated Facile Greener Multicomponent Synthesis of 2,4-Diaryl-quinoline Derivatives in Water

Author(s)

Martins, Lucas Michelao ; Moreno, Vitor Fernandes ; Rosario, Ilana Sganzerla ; de Oliveira Graeff, Carlos Frederico ; Silva Filho, Luiz Carlos

• Document type: Journal article
• Source: ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY; v. 14, n. 1, p. 9-pg., 2021-01-01.

Abstract

Quinolines are an important class of natural and synthetic products, with several biological activity and applications in medicine and electronics. In this work we present a greener method of synthesis of 2,4-diarylquinoline derivatives by an easy one-pot multicomponent reaction between aniline derivatives, aldehyde derivatives and phenylacetylene in water, with hydrochloric acid as promoter. With this method we could synthesize several compounds with good yield and reaction time, including new alkylamino-containing 2,4-diarylquinoline derivatives that could not be synthesized with niobium pentachloride catalyst in similar conditions. [GRAPHCS] (AU)

• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/14506-7 - Study about the one-pot synthesis and application as organic dyes of quinolone and anthrazoline derivatives
• Grantee: Luiz Carlos da Silva Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/01599-1 - Studies about the use of NbCl5 in multicomponent reactions for the synthesis of organic dyes
• Grantee: Luiz Carlos da Silva Filho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/09235-4 - Synthesis of reduced graphene oxide modified with quinoline derivatives for solar cell applications.
• Grantee: Lucas Michelão Martins
• Support Opportunities: Scholarships in Brazil - Post-Doctoral