| Full text | |
| Author(s): Show less - |
Gross, Rudiger
;
Dias Loiola, Livia Mesquita
;
Issmail, Leila
;
Uhlig, Nadja
;
Eberlein, Valentina
;
Conzelmann, Carina
;
Olari, Lia-Raluca
;
Rauch, Lena
;
Lawrenz, Jan
;
Weil, Tatjana
;
Mueller, Janis A.
;
Cardoso, Mateus Borba
;
Gilg, Andrea
;
Larsson, Olivia
;
Hoeglund, Urban
;
Palsson, Sandra Axberg
;
Tvilum, Anna Selch
;
Lovschall, Kaja Borup
;
Kristensen, Maria M.
;
Spetz, Anna-Lena
;
Hontonnou, Fortune
;
Galloux, Marie
;
Grunwald, Thomas
;
Zelikin, Alexander N.
;
Munch, Jan
Total Authors: 25
|
| Document type: | Journal article |
| Source: | ADVANCED SCIENCE; v. N/A, p. 17-pg., 2022-05-11. |
| Abstract | |
Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core-shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses. (AU) | |
| FAPESP's process: | 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles |
| Grantee: | Watson Loh |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/17028-1 - Zika Virus Irreversible Inactivation by Dendritic Copolymers as Broad-Spectrum Antiviral Agents |
| Grantee: | Lívia Mesquita Dias Loiola |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |