Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2

Author(s):Show less -

Gross, Rudiger ; Dias Loiola, Livia Mesquita ; Issmail, Leila ; Uhlig, Nadja ; Eberlein, Valentina ; Conzelmann, Carina ; Olari, Lia-Raluca ; Rauch, Lena ; Lawrenz, Jan ; Weil, Tatjana ; Mueller, Janis A. ; Cardoso, Mateus Borba ; Gilg, Andrea ; Larsson, Olivia ; Hoeglund, Urban ; Palsson, Sandra Axberg ; Tvilum, Anna Selch ; Lovschall, Kaja Borup ; Kristensen, Maria M. ; Spetz, Anna-Lena ; Hontonnou, Fortune ; Galloux, Marie ; Grunwald, Thomas ; Zelikin, Alexander N. ; Munch, Jan

• Document type: Journal article
• Source: ADVANCED SCIENCE; v. N/A, p. 17-pg., 2022-05-11.

Abstract

Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core-shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses. (AU)

• FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/17028-1 - Zika Virus Irreversible Inactivation by Dendritic Copolymers as Broad-Spectrum Antiviral Agents
• Grantee: Lívia Mesquita Dias Loiola
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor