| Full text | |
| Author(s): Show less - |
Pinho, Mariana P.
;
Lepski, Guilherme A.
;
Rehder, Roberta
;
Chauca-Torres, Nadia E.
;
Evangelista, Gabriela C. M.
;
Teixeira, Sarah F.
;
Flatow, Elizabeth A.
;
de Oliveira, Jaqueline V.
;
Fogolin, Carla S.
;
Peres, Nataly
;
Arevalo, Analia
;
Alves, Venancio
;
Barbuto, Jose A. M.
;
Bergami-Santos, Patricia C.
Total Authors: 14
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 10, p. 10-pg., 2022-05-01. |
| Abstract | |
Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic-tumor cell fusion vaccine. CST showed a near-complete tumor response, with a marked improvement in her functional status and simultaneous increases in tumor-specific CD8+ and CD4+ T cells. Two months before recurrence, the frequency of tumor-specific T cells decreased, while that of IL-17 and CD4+ T cells increased. CST passed away 15 months after enrollment. In this illustrative case, the tumor-specific CD4+ T-cell numbers and phenotype behaved as treatment efficacy biomarkers, highlighting the key role of the latter in glioblastoma immunotherapy. (AU) | |
| FAPESP's process: | 14/25988-1 - Analysis of the T cell repertoire in cancer patients: unveiling the antitumor immune response in humans |
| Grantee: | Mariana Pereira Pinho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/01137-8 - Analysis of the tumor-antigen specific T cell repertoire in healthy donors using T cell libraries |
| Grantee: | Mariana Pereira Pinho |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |