| Full text | |
| Author(s): |
Donega Zafalon, Geraldo Francisco
;
Gomes, Vitoria Zanon
;
Amorim, Anderson Rici
;
Valencio, Carlos Roberto
;
Filipe, J
;
Smialek, M
;
Brodsky, A
;
Hammoudi, S
Total Authors: 8
|
| Document type: | Journal article |
| Source: | PROCEEDINGS OF THE 23RD INTERNATIONAL CONFERENCE ON ENTERPRISE INFORMATION SYSTEMS (ICEIS 2021), VOL 1; v. N/A, p. 8-pg., 2021-01-01. |
| Abstract | |
The multiple sequence alignment is one of the main tasks in bioinformatics. It is used in different important biological analysis, such as function and structure prediction of unknown proteins. There are several approaches to perform multiple sequence alignment and the use of heuristics and meta-heuristics stands out because of the search ability of these methods, which generally leads to good results in a reasonable amount of time. The progressive alignment and genetic algorithm are among the most used heuristics and meta-heuristics to perform multiple sequence alignment. However, both methods have disadvantages, such as error propagation in the case of progressive alignment and local optima results in the case of genetics algorithm. Thus, this work proposes a new hybrid refinement phase using a progressive approach to locally realign the multiple sequence alignment produced by genetic algorithm based tools. Our results show that our method is able to improve the quality of the alignments of all families from BAliBase. Considering Q and TC quality measures from BaliBase, we have obtained the improvements of 55% for Q and 167% for TC. Then, with these results we can provide more biologically significant results. (AU) | |
| FAPESP's process: | 19/00030-3 - Hybrid strategy in genetic algorithms to improve multiple sequence alignments |
| Grantee: | Vitoria Zanon Gomes |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |