Biological Properties of Extracts from Byrsonima Species in Microemulsions

Author(s)

Lima Neto, Jose de Sousa ; Marena, Gabriel Davi ; Girotto, Luiza ; Magorpo, Vanessa ; dos Santos Ramos, Matheus Aparecido ; da Silva, Patricia Bento ; Chorilli, Marlus ; Bauab, Tais Maria ; Resende, Flavia Aparecida

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 32, n. 3, p. 6-pg., 2022-04-29.

Abstract

The Byrsonima genus, Malpighiaceae, represents a rich source of phenolic compounds with proven pharmacological properties (antiulcerogenic, antimicrobial, antimutagenic, and antioxidant activities). In this context, the aim of the present study was to identify chemical compounds employing UPLC-PDA-ESI-QTOF-MS/MS and FIA-ESI-IT-MSn and evaluate the antimicrobial activity and toxicogenctic effects of hydroethanolic extracts obtained from B. coccolobifolia Kunth and B. ligustrifolia Mart. incorporated and not incorporated in microemulsions. The former presents grape seed oil and cholesterol at a 5:1 ratio, as an oily phase (10%) (microemulsion 1) and the other, only cholesterol (microemulsion 2). Both extracts and their formulations exhibited greater antifungal potential compared to antibacterial. The formulations, however, were highly cytotoxicity compared to free extracts and exhibited a lower selectivity index. The B. ligustrifolia formulations did not present mutagenic activity and inhibited previously detected extract mutagenicity, while B. coccolobifolia formulations microemulsion 2 induced mutations of the base pair substitution type in Typhimurium strains and oxidative damage in TA102 when assessed by the Ames test. (AU)

• FAPESP's process: 19/06818-1 - Evaluation of the antifungal and genotoxicological activities of Byrsonima ligustrifolia extract incorporated or not in microemulsions
• Grantee: Vanessa Magorpo
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/16278-9 - Study of the genotoxicological potential and permeation assay with Caco-2 cells of metallic complexes with promising biological activities
• Grantee: Flávia Aparecida Resende Nogueira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/01381-1 - Evaluation of the influence of a nanotechnological system on the antibacterial, mutagenic and cytotoxic activities induced by extracts of Byrsonima coccolobifolia
• Grantee: Luiza Girotto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation