How different is invasive fusariosis in pediatric patients than in adults? A systematic review

Author(s)

Rossato, Luana ; Carlesse, Fabianne ; de Almeida, Joao Nobrega, Jr. ; Kontoyiannis, Dimitrios P. ; Colombo, Arnaldo Lopes

• Document type: Journal article
• Source: Current Opinion in Infectious Diseases; v. 34, n. 6, p. 8-pg., 2021-12-01.

Abstract

Purpose of review To investigate the peculiarities of invasive fusariosis (IF) in pediatric patients. Methods We conducted a systematic literature review to identify human cases of locally invasive and systemic fusariosis documented in children (up to 18 years) published between 1973 (first case report) and 2021. Recent findings One hundred and six cases were retrieved, and hematologic malignancy was reported in 64% (68/106) of the cases. The most frequent anatomic sites involved were skin 66% (70/106), blood 47% (50/106), and lungs 35% (37/106), bone and joint (8%, 09/106), and eye/central nervous system involvement (8%, 9/106). Fusarium solani, followed by Fusarium oxysporum, were the most commonly reported species. In disseminated fusariosis, relapsed or refractory baseline disease (P<0.001, OR=10.555, CI 95% 3.552-31.365) was associated with poor outcome, whereas voriconazole-based therapy was associated with better prognosis (P = 0.04, OR = 0.273, CI 95% 0.076-0.978). Summary Hematologic malignancies and solid tumors requiring intensive immunosuppression are the main conditions related to IF in children where other organs than skin, blood, and lungs were frequently involved. Voriconazole therapy appears to be also effective in children with IF, despite the wide pharmacokinetic variability of this triazole in pediatric patients. (AU)

• FAPESP's process: 18/19347-4 - Characterization of molecular mechanisms related to azoles resistance in Trichosporon asahii clinical isolates
• Grantee: João Nóbrega de Almeida Júnior
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 17/02203-7 - Multidisciplinary and international network to characterize microbiological aspects and natural history of invasive fungal infections due Candida spp
• Grantee: Arnaldo Lopes Colombo
• Support Opportunities: Research Projects - Thematic Grants