Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Could dysregulation of RASSF1 expression be a mechanism of tumorigenesis in CTVT?

Full text
Author(s):
Haline B. Fêo [1] ; Luis Mauricio M. Flórez ; Ricardo S. Yamatogi [3] ; Anderson P. Duzanski ; João P. Araújo Junior [5] ; Rogerio A. Oliveira [6] ; Noeme S. Rocha [7]
Total Authors: 7
Affiliation:
[1] Universidade Estadual Paulista. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Clínica Veterinária - Brasil
[3] Universidade Federal de Viçosa. Departamento de Veterinária - Brasil
[5] Universidade Estadual Paulista. Instituto de Biociências. Laboratório de Virologia - Brasil
[6] Universidade Estadual Paulista. Instituto de Biociências. Departamento de Bioestatística - Brasil
[7] Universidade Estadual Paulista. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Clínica Veterinária - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 42, 2022-07-29.
Abstract

ABSTRACT: Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It is a transmissible cancer that propagates naturally in dogs and reportedly contains gene mutations. RASSF1 participates in DNA damage repair, and its downregulation, results in tumor progression. Hence, RASSF1 is a tumor suppressor gene. Its expression was quantified in tumors from seventeen animals and three cell cultures derived from tumors. In general, RASSF1 was underexpressed in 65%, and absent in 35% of tumor samples. Cells from tumor tissue cultures showed decreased expression of RASSF1 in 67% and elevated expression in 33% of samples tested. The tumor tissues showed significantly lower levels of RASSF1 expression compared to cultured cells. Previously we reported that both the tumor microenvironment and the host immune system appear to influence the tumorigenesis and stage of CTVT. This is the first article to demonstrate the expression of RASSF1 in CTVT. Decreased RASSF1 possibly helps tumor progression. (AU)

FAPESP's process: 12/19285-2 - Gene expression of MDR-1, TP53, Bcl-2 and Bax in canine transmissible venereal tumor and its relationship to aggression and response to therapy
Grantee:Noeme Sousa Rocha
Support Opportunities: Regular Research Grants