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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fluorescence spectroscopy for clinical transplantation liver grafts monitoring: possibilities offered by 408 nm excitation

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Author(s):
José Dirceu Vollet-Filho [1] ; Juliana Ferreira-Strixino ; Rodrigo Borges Correa [3] ; Vanderlei Salvador Bagnato [4] ; Orlando de Castro e Silva Júnior [5] ; Cristina Kurachi [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Instituto de Física de São Carlos. Departamento de Física e Ciência dos Materiais - Brasil
[3] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia - Brasil
[4] Universidade de São Paulo. Instituto de Física de São Carlos. Departamento de Física e Ciência dos Materiais - Brasil
[5] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Cirurgia e Anatomia - Brasil
[6] Universidade de São Paulo. Instituto de Física de São Carlos. Departamento de Física e Ciência dos Materiais - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 37, n. 9 2022-12-12.
Abstract

ABSTRACT Purpose: Fluorescence spectroscopy techniques have been investigated aiming to reduce the invasiveness of methods for investigation of tissue. In transplantation procedures, it may offer the possibility of a complementary technique for the monitoring of liver grafts’ conditions prior to and during the transplantation procedure stages involving cold perfusion. The objective of this study was to evaluate fluorescence spectroscopy under violet light excitation (408 nm) for the monitoring of clinical hypothermic liver transplantation procedures. Methods: Organ grafts were monitored from before the removal of the donor’s body to 1 h after the implant into the receptor’s body. Fluorescence spectroscopy was assessed over five stages within these transplant stages. Results: The study provided evidence of a correlation between fluorescence information collected during liver grafts transplantation and the survival of patients. Conclusions: Fluorescence spectroscopy can become a tool to monitor transplantation grafts, providing objective information for the final decision of surgeons to use organs. (AU)

FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 98/14270-8 - Center for Optical and Photonics Science
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC