| Full text | |
| Author(s): |
Fernanda da Silva Santos
[1]
;
Felipe Hideo Ikeda
[2]
;
Mirna Duarte Barros
[3]
;
André de Campos Duprat
[4]
Total Authors: 4
|
| Affiliation: | [1] Irmandade da Santa Casa de Misericórdia de São Paulo. Departamento de Otorrinolaringologia - Brasil
[2] Irmandade da Santa Casa de Misericórdia de São Paulo. Departamento de Otorrinolaringologia - Brasil
[3] Faculdade de Ciências Médicas da Santa Casa de São Paulo. Departamento de Morfologia - Brasil
[4] Irmandade da Santa Casa de Misericórdia de São Paulo. Departamento de Otorrinolaringologia - Brasil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Otorhinolaryngology; v. 88, p. 102-107, 2023-01-13. |
| Abstract | |
Abstract Introduction A challenge in phonosurgery is achieving good vocal quality with minimal vocal fold fibrosis. Fibrin glue can be applied to minimize fibrosis; however, its use in the larynx is based primarily on clinical experience, particularly in extensive lesions. Objective The objective of this study was to evaluate the effect of application of fibrin glue on collagen concentration at the late phase of the healing process after detaching a pedicled flap of the vocal fold cover in rabbits. Methods In this prospective animal study, twelve adult male rabbits underwent laryngeal microsurgery, in which an incision was made along the entire length of both vocal folds, followed by extensive mucosal detachment and section of the incision ends. Fibrin glue was applied in the left vocal fold, and the mucosa was repositioned. In the right vocal fold, the mucosa was repositioned without treatment with fibrin glue. After 3-months, the rabbits were euthanized. Histological analyses were performed, and the data collected were subjected to statistical analysis. Results Vocal folds treated with fibrin glue presented higher collagen concentration in Masson trichrome staining and significantly higher (p< 0.05) collagen concentration in picrosirius red staining compared to control vocal folds. Conclusion Treatment with fibrin glue led to greater vocal fold fibrogenesis in the present study. Nonetheless, further studies are necessary to determine the prophylactic effect of sealants in laryngeal surgeries that require extensive detachment of the vocal fold cover. (AU) | |
| FAPESP's process: | 14/10767-0 - Interference application of triamcinolone with or without fibrin glue in the vocal fold scarring of rabbits after surgical manipulation |
| Grantee: | André de Campos Duprat |
| Support Opportunities: | Regular Research Grants |