Advanced search
Start date
Betweenand
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ANTI-Trypanosoma cruzi PHENYLPROPANOIDS ISOLATED FROM Baccharis ligustrina C. DC. (ASTERACEAE).

Full text
Author(s):
Matheus L. Silva [1] ; Leila Gimenes [2] ; Paulete Romoff [3] ; Marisi G. Soares [4] ; Fernanda F. Camilo [5] ; Erica Valadares de C. Levatti [6] ; Andre G. Tempone [7] ; João Henrique G. Lago [8]
Total Authors: 8
Affiliation:
[1] Universidade Federal do ABC. Centro de Ciências Naturais e Humanas - Brasil
[2] Instituto Agronômico de Campinas. Centro de Pesquisa e Desenvolvimento de Recursos Genéticos Vegetais - Brasil
[3] Universidade Presbiteriana Mackenzie. Centro de Ciências e Humanidades - Brasil
[4] Universidade Federal de Alfenas. Instituto de Química - Brasil
[5] Instituto Adolfo Lutz. Centro de Parasitologia e Micologia - Brasil
[6] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[7] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[8] Universidade Federal do ABC. Centro de Ciências Naturais e Humanas - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Química Nova; v. 46, n. 1, p. 39-42, 2023-03-03.
Abstract

In the present work, dried aerial parts of Baccharis ligustrina (Asteraceae) were subjected to microwave assisted extraction (MAE) using aqueous solution of 1-butyl-3-methylimidazolium bromide (BMImBr) and the obtained extract was successively partitioned using hexane and EtOAc. Using reduced amounts of extracts and efficient chromatographic steps, four acyl C6C3 derivatives (n-hexacosyl ferulate, n-hexacosyl, n-octacosyl, and n-triacontyl p-coumarates) were obtained from hexane phase whereas two C6C3 acids (ferulic and p-coumaric) were obtained from EtOAc phase. Isolated phenylpropanoids were evaluated against amastigote forms of parasite Trypanosoma cruzi. As result, it was observed that p-coumaric and ferulic acids were inactives whereas alkyl derivatives displayed EC50 values of 6.5 µmol L-1 (n-octacosyl p-coumarate), 9.3 µmol L-1 (n-triacontyl p-coumarate), 15.7 µmol L-1 (n-hexacosyl p-coumarate), and 32.2 µmol L-1 (n-hexacosyl ferulate). All tested compounds displayed reduced toxicity against NCTC cells (CC50 > 200 mmol L-1). (AU)

FAPESP's process: 21/02789-7 - Search for bioactive metabolites with antiparasitic action in plant species from Atlantic Forest and Cerrado regions - a chemical, phenotypical, and metabolomic approach
Grantee:João Henrique Ghilardi Lago
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants