| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Universidade Federal de São Paulo. Escola Paulista de Medicina. Disciplina de Mastologia - Brasil
[2] UNIFESP. Departamento de Ginecologia
[3] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Ginecologia e Obstetrícia; v. 28, n. 10, p. 581-589, 2006-10-00. |
| Abstract | |
PURPOSE: To assess the presence of estrogen receptor gene polymorphisms HaeIII and MspI as well as clinical factors, and their possible associations with high mammographic density in post-menopausal women. METHODS: One hundred and fifteen post-menopausal women, not in use of hormonal therapy and without clinical or mammographic lesions were evaluated. Three independent observers have determined the mammographic density pattern based on the ACR-BIRADS® 2003 (two subjective and one objective evaluations - Adobe Photoshop 7.0 software). Oral swabs (Cytobrush) were obtained to extract DNA and the polymerase chain reaction - restriction fragment length polymorphism) was performed to assess the presence of polymorphisms in intron 1 and exon 1 from estrogen receptor gene (HaeIII and MspI). RESULTS: The HaeIII polymorphism was found in 43 (37.4%) of the 115 women, while MspI was found in 96 (83.5%) of them. There was a good agreement among determinations of the three observers with regard to mammographic density. Thirty-four (29.6%) women had dense breasts and eighty-one (70.4%) had non-dense breasts. CONCLUSION: The estrogen receptor gene polymorphism Haelll showed no association with mammographic density (Fisher = 0.712), while the association between estrogen receptor gene polymorphism Mspl and mammographic density was near significance (Fisher = 0.098). The associations among age, parity and body mass index revealed statistical significance. (AU) | |
| FAPESP's process: | 03/04533-1 - Study of polymorphisms in genes responsible for biosynthesis, action and metabolization of sexual steroids in estrogen-dependent and menopausal gynecological conditions |
| Grantee: | Ismael Dale Cotrim Guerreiro da Silva |
| Support Opportunities: | Research Projects - Thematic Grants |