| Full text | |
| Author(s): |
Julia Takuno Hespanhol
[1]
;
Lior Karman
[2]
;
Daniel Enrique Sanchez-Limache
[3]
;
Ethel Bayer-Santos
[4]
Total Authors: 4
|
| Affiliation: | [1] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[2] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[3] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[4] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia - Brasil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 46, n. 1 2023-03-06. |
| Abstract | |
Abstract Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, and contact-dependent effectors that are either secreted in the medium or directly translocated into target cells. During bacterial antagonistic encounters, several cellular components important for life become a weak spot prone to an attack. Nucleic acids and the machinery responsible for their synthesis are well conserved across the tree of life. These molecules are part of the information flow in the central dogma of molecular biology and mediate long- and short-term storage for genetic information. The aim of this review is to summarize the diversity of antibacterial molecules that target nucleic acids during antagonistic interbacterial encounters and discuss their potential to promote the emergence antibiotic resistance. (AU) | |
| FAPESP's process: | 22/01364-5 - Functional characterization of a new T6SS antibacterial effector of Salmonella enterica |
| Grantee: | Julia Takuno Hespanhol |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 22/01444-9 - Analysis of the contribution of a new antibacterial T6SS effector of Salmonella enterica serovar Oslo in bacterial competitions |
| Grantee: | Lior Karman |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 19/22715-8 - Function of Salmonella bongori SPI-22 T6SS in bacterial competitions and interactions with phagocytic host cells |
| Grantee: | Daniel Enrique Sánchez Limache |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 18/04553-8 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells |
| Grantee: | Ethel Bayer Santos |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 17/02178-2 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells |
| Grantee: | Ethel Bayer Santos |
| Support Opportunities: | Research Grants - Young Investigators Grants |