Infection caused by Candida auris: state of the art

Author(s):Show less -

Marena, G. D. ; Carvalho, G. C. ; Monazzi, L. C. S. ; Maschio-Lima, T. ; De Almeida, M. T. G. ; Da Silva, J. L. M. ; Fortunato, G. C. ; Araujo, V. H. S. ; Venancio, D. C. V. ; Chang, M. R. ; Chorilli, M.

• Document type: Journal article
• Source: MYCOSPHERE; v. 13, n. 1, p. 42-pg., 2022-01-01.

Abstract

Candida auris, a new emerging yeast that was isolated for the first time in 2009 in the ear canal of a Japanese patient, are increasingly been associated with outbreaks, threatening the whole world. As a highly lethal and contagious microorganism, C. auris can be considered a threat to public health, mainly due to the high death rate in hospital environments and ability to resist to the main first-line antifungal agents (echinocandins, azoles and polyenes), which limits its treatment and infection control. As it is a microorganism with little scientific and clinical knowledge, controlling its infection is still a great challenge. Faced with the worrying situation, this review presents important information concerning the morphology and biology of C. auris, as well as resistance mechanisms, updated epidemiology, virulence, immune response escape mechanisms, pathogenesis and processor involved in the pathogenesis mechanism, clinical manifestations, laboratory diagnosis and sample collection methods, molecular diagnostics, treatment of infection (main drugs used and future therapies) and prophylactic methods, with the objective not only of clarifying doubts of the scientific and medical population, but also of helping to control new outbreaks of C. auris worldwide. (AU)

• FAPESP's process: 19/09831-9 - Nanoemulsion for co-encapsulation on amphotericin B and micafungin: development and characterizations of the in vitro and in vivo Candida auris potential.
• Grantee: Gabriel Davi Marena
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/26821-7 - Nano-in-nano containing curcumin and benzydamine hydrochloride for the treatment of Vulvovaginal Candidiasis: from development to biological application in vitro and in vivo
• Grantee: Gabriela Corrêa Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate