In vivo schistosomicidal activity of (+/-)-licarin A-loaded poly (epsilon-caprolactone) nanoparticles

Author(s):Show less -

Lima, Thais C. ; Magalhaes, Lizandra G. ; Paula, Lucas A. de L. ; Cunha, Wilson R. ; Januario, Ana H. ; Pauletti, Patricia M. ; Bastos, Jairo K. ; Mnuquian, Hallana Alves ; Forim, Moacir R. ; Morais-Urano, Raquel P. ; Laurentiz, Rosangela S. ; Tondato, Wellington N. ; Molina, Eduardo F. ; Santos, Mario F. C. ; Silva, Marcio L. A. E.

• Document type: Journal article
• Source: Experimental Parasitology; v. 241, p. 7-pg., 2022-09-01.

Abstract

Schistosomiasis mansoni is an infectious parasitic disease caused by worms of the genus Schistosoma, and pra-ziquantel (PZQ) is the medication available for the treatment of schistosomiasis. However, the existence of resistant strains reinforces the need to develop new schistosomicidal drugs safely and effectively. Thus, the (& PLUSMN;)-licarin A neolignan incorporated into poly-8-caprolactone (PCL) nanoparticles and not incorporated were evaluated for their in vivo schistosomicidal activity. The (& PLUSMN;)-licarin A-loaded poly(epsilon-caprolactone) nanoparticles and the pure (& PLUSMN;)-licarin A showed a reduction in the number of worm eggs present in spleens of mice infected with Schistosoma mansoni. In addition, the (& PLUSMN;)-licarin A incorporated in the concentration of 20 mg/kg and 200 mg/kg reduced the number of worms, presenting percentages of 56.3% and 41.7%, respectively. (AU)

• FAPESP's process: 18/05080-6 - Multi-user equipment approved in grant 2017/04138-8 for high pressure semipreparative chromatographic system model LC-20AR
• Grantee: Sergio Ricardo Ambrosio
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 18/25010-2 - Isolation and identification of green and brown propolis constituents.
• Grantee: Mário Ferreira Conceição Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 10/17378-8 - Study of the immunomodulatory activity of lignans and neolignans obtained by partial synthesis and oxidative coupling as a potential in developing new antiparasitic drugs
• Grantee: Márcio Luís Andrade e Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/15207-4 - Evaluation of the effect of lignans and neolignans on Schistosoma mansoni: a proteomic study
• Grantee: Lizandra Guidi Magalhães
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/07623-8 - The use of quantum-mechanical methods to study the bonds and chemical interactions in self-organizing systems with applications in catalysis, medicinal chemistry, electrochromism, energy storage and conversion
• Grantee: Renato Luis Tame Parreira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 11/05952-4 - Preparation and characterization of polymeric nanoparticles containing (-)-6,6'-dinitrohinokinin and (±)-licarina-A as potential drugs in the assessment of the schistosomicidal activity
• Grantee: Thaís Coelho Lima
• Support Opportunities: Scholarships in Brazil - Doctorate