| Full text | |
| Author(s): Show less - |
Damas, Ingrid Iara
;
Lavareze, Luccas
;
Scarini, Joao Figueira
;
de Lima-Souza, Reydson Alcides
;
Emerick, Carolina
;
Goncalves, Mayara Trevizol
;
Figueiredo-Maciel, Tayna
;
Vieira, Gustavo de Souza
;
Kimura, Talita de Carvalho
;
Aquino, Iara Goncalves
;
Goncalves de Paiva, Joao Paulo
;
Helms, My N.
;
Mariano, Fernanda Viviane
;
Altemani, Albina
;
Abu Egal, Erika Said
Total Authors: 15
|
| Document type: | Journal article |
| Source: | Placenta; v. 131, p. 9-pg., 2023-01-01. |
| Abstract | |
Villitis of unknown etiology (VUE) is an inflammatory disease characterized by the infiltration of maternal CD8 +T cells into the placental villi. Although the pathogenesis of VUE is still debated, dysregulation of the immune system appears to be an important factor in the development of the disease. Interaction of maternal T cells with the fetal antigens seems to be the trigger for the VUE onset. In this context, graft vs host disease (GVHD) and allographic rejection seem to share similarities in the VUE immunopathological mechanism, especially those related to immunoregulation. In this review, we compared the immunological characteristics of VUE with allograft rejection, and GVHD favoring a better knowledge of VUE pathogenesis that may contribute to VUE therapeutics strategies in the future. (AU) | |
| FAPESP's process: | 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma |
| Grantee: | João Figueira Scarini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 20/08431-4 - METABOLOMIC PROFILING ANALYSIS IN THE MALIGNANT TRANSFORMATION OF PLEOMORPHIC ADENOMA |
| Grantee: | Reydson Alcides de Lima Souza |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry |
| Grantee: | Fernanda Viviane Mariano Brum Corrêa |
| Support Opportunities: | Research Grants - Young Investigators Grants |