Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model

Author(s)

Motta, Gabriela Hering ; Guimaraes, Leticia Patricia ; Fernandes, Elaine Raniero ; Guedes, Fernanda ; Marques de Sa, Lilian Rose ; Silva, Sandriana dos Ramos ; Ribeiro, Orlando Garcia ; Santos Katz, Iana Suly

• Document type: Journal article
• Source: Journal of Neuroimmunology; v. 373, p. 13-pg., 2022-10-18.

Abstract

Rabies virus (RABV) is a neurotropic virus that causes fatal neuroinflammation in mammals. The insectivorous bat RABV strains are less pathogenic for mice than strains associated with other reservoirs. We characterized the tissue inflammatory response in the CNS of RABV isolated from insectivorous bats. Eptesicus furinalis (EPBRV)-infected mice had a robust inflammatory response and a greater amount of IL-1 beta, IL-6 and TNF-alpha, while Myotis nigricans (MNBRV)-infected mice showed a higher expression of IL-17 and greater activation of IFN-beta. New approaches to understand the inflammatory response to different mechanisms of action may provide insights for the development of novel therapies for rabies. (AU)

• FAPESP's process: 17/08215-7 - Pathology and Immunopathology in Rabies Virus-Infected Mice Isolated From Insectivorous Bats
• Grantee: Iana Suly Santos Katz
• Support Opportunities: Regular Research Grants