Research Grants 17/08215-7 - Raiva, Replicação viral - BV FAPESP
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Pathology and Immunopathology in Rabies Virus-Infected Mice Isolated From Insectivorous Bats

Abstract

Rabies is a viral and fatal zoonosis, causes an acute, progressive encephalitis that remains an importance in public health. In the last few year, we can observe a change in the epidemiological profile after canine rabies control in São Paulo city, leading to a significant increase of human rabies cases associated with bats. Thus, it is important to have an understanding of the rabies virus (RABV) pathogenesis caused by isolates from Eptesicus sp and Myotis sp due to the increasing number of contact among bats with humans being and pets in the urban environment and their correlation with human rabies cases. Therefore, the aim of this study is to investigate RABV-infected mice isolated from insectivorous bats for clinical signs, histopathological alterations by hematoxylin-eosin staining and tissue immune responses by immunohistochemistry in the Central Nervous System, as well determine virus spread, growth curves and kinetics of virus internalization using culture cells. Thereby, this study may contribute to our understanding of the pathogenesis of RABV infection maintained in insectivorous bats determined. And it may help in the advancement of therapies, in the epidemiological surveillance and in the implementation of rabies control strategy. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUOCO, NATALIA LANGENFELD; FERNANDES, ELAINE RANIERO; SILVA, SANDRIANA DOS RAMOS; LUIZ, FERNANDA GUEDES; RIBEIRO, ORLANDO GARCIA; SANTOS KATZ, IANA SULY. Street rabies virus strains associated with insectivorous bats are less pathogenic than strains isolated from other reservoirs. Antiviral Research, v. 160, p. 94-100, . (17/08215-7)
MOTTA, GABRIELA HERING; GUIMARAES, LETICIA PATRICIA; FERNANDES, ELAINE RANIERO; GUEDES, FERNANDA; MARQUES DE SA, LILIAN ROSE; SILVA, SANDRIANA DOS RAMOS; RIBEIRO, ORLANDO GARCIA; SANTOS KATZ, IANA SULY. Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model. Journal of Neuroimmunology, v. 373, p. 13-pg., . (17/08215-7)

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