Static magnetic field blocked alprazolam-induced behavior of Wistar rats in the elevated plus-maze test

Author(s)

Brito, Raquel Cardoso ; Olivato, Thairyne ; Kitabatake, Takae Tamy ; Zhang, Kelly ; Guirro, Elaine Caldeira de Oliveira ; de Araujo, Joao Eduardo

• Document type: Journal article
• Source: Neuroscience Letters; v. 794, p. 6-pg., 2023-01-18.

Abstract

Studies have shown that psychotropic drugs change rat behavior in the elevated plus-maze test (EPM). This study investigated whether static magnetic fields could alter alprazolam-induced rat behavior in the EPM. 66 male Wistar rats (270-300 g weight) were assigned to one of the following groups: Sham Magnetic + Saline (SMS), North Pole + Saline (NPS), South Pole + Saline (SPS), Sham magnetic + alprazolam (SMA), NP + alprazolam (NPA), and SP + alprazolam (SPA). After five days of static magnetic stimulation (3200 Gauss), they received alprazolam or saline (1 mg/kg), and their behavior was evaluated. Two-way ANOVA and Holm-Sidak post-hock were used, with a significant P value of <0.05. The SMA and NPA groups showed an increased number of entries and time in the open arms compared with the SMS group. SPA showed a decrease in these measures when compared to SMA [F(2,61) = 6.43 and F(2,61) = 3.72, respectively]. The SMA and NPA groups showed increased head dipping and end-arm activity compared with the SMS group. SPA showed a decrease in these measures when compared to SMA [F(2,61) = 3.37 and [F(2,61) = 4.72, respectively]. These results show that the south magnetic pole of a static magnetic field blocked the alprazolam effect in the space-time variables of the open arms and ethological anxiolytic-like behavior in the EPM. (AU)

• FAPESP's process: 14/26561-1 - Functional analysis of the continuous magnetic field in healthy and ischemic rodent's post-injection of anxiolytic, anxiogenic, activator and depressor of motor behavior
• Grantee: João Eduardo de Araujo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/07730-0 - Morphological and Behavioral Changes in Ischemic Gerbils Induced by Exposure to Nicotine and Forced Continuous Treadmill Training.
• Grantee: Takae Tamy Kitabatake
• Support Opportunities: Scholarships in Brazil - Master