The role of residual renal function on potassium intake and excretion in patients on peritoneal dialysis

Author(s)

Claudino, Gabriele ; Ramos, Christiane Ishikawa ; de Andrade, Laila Santos ; Ferreira Pereira, Natalia Barros ; Teixeira, Renata Rodrigues ; Santos Muniz, Gisselma Aliny ; Bezerra Di Medeiros Leal, Maria Carolina ; Cuppari, Lilian

• Document type: Journal article
• Source: INTERNATIONAL UROLOGY AND NEPHROLOGY; v. N/A, p. 8-pg., 2023-01-17.

Abstract

BackgroundPatients on chronic dialysis are at increased risk of developing disorders in potassium balance. The preservation of residual renal function (RRF), frequently observed in patients on peritoneal dialysis (PD), may contribute to better control of serum potassium. This study aimed to investigate the role residual renal function on potassium intake and excretion in PD patients.MethodsIn this cross-sectional study, dietary potassium was evaluated by the 3-day food record. Potassium concentration was determined in serum, 24 h dialysate, stool ample, and 24 h urine of patients with diuresis > 200 mL/day, who were considered non-anuric.ResultsFifty-two patients, 50% men, 52.6 +/- 14.0 years, and PD vintage 19.5 [7.0-44.2] months, were enrolled. Compared to the anuric group (n = 17, 33%), the non-anuric group (n = 35, 67%) had lower dialysate potassium excretion (24.8 +/- 5.3 vs 30.9 +/- 5.9 mEq/d; p = 0.001), higher total potassium intake (44.5 +/- 16.7 vs 35.1 +/- 8.1 mEq/d; p = 0.009) and potassium intake from fruit (6.2 [2.4-14.7] vs 2.9 [0.0-6.0]mEq/d; p = 0.018), and no difference in serum potassium (4.8 +/- 0.6 vs 4.8 +/- 0.9 mEq/L; p = 0.799) and fecal potassium (2.2 +/- 0.5 vs 2.1 +/- 0.7 mEq/L; p = 0.712). In non-anuric patients, potassium intake correlated directly with urinary potassium (r = 0.40; p = 0.017), but not with serum, dialysate, or fecal potassium. In the anuric group, potassium intake tended to correlate positively with serum potassium (r = 0.48; p = 0.051) and there was no correlation with dialysate or fecal potassium.ConclusionThe presence of residual renal function constitutes an important factor in the excretion of potassium, which may allow the adoption of a less-restrictive diet. (AU)

• FAPESP's process: 18/12122-7 - Effect of unripe banana flour on intestinal micribiota and on uremic toxins in patients on peritoneal dialysis.
• Grantee: Lilian Cuppari
• Support Opportunities: Regular Research Grants