A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine

Author(s)

Gimenes, G. M. ; Santana, G. O. ; Scervino, M. V. M. ; Curi, R. ; Pereira, J. N. B.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 55, n. 1, p. 10-pg., 2022-01-01.

Abstract

The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state. (AU)

• FAPESP's process: 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise
• Grantee: Rui Curi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/19097-0 - Inflammation involvement in the hypertrophic response of the skeletal muscle in Type I Diabetic rats
• Grantee: Maria Vitoria Martins Scervino
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 19/01942-6 - Neurochemical characterization of mioenteric plexus of Goto-Kakizaki rat intestine
• Grantee: Gabriela Mandu Gimenes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation