Photodynamic therapy of adenoid hypertrophy in acute rhinosinusitis

Author(s)

Blanco, Kate Cristina ; Silva, Ana Paula da ; Panhoca, Vitor Hugo ; Moriyama, Lilian Tan ; Bagnato, Vanderlei Salvador

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 39, p. 3-pg., 2022-05-23.

Abstract

A first step for microorganisms to reach the respiratory system and cause infectious disease is colonization in the nasopharynx. Humans inhale a bacterial load of up to 10(6) per cubic meter of air per day [1], including transient microorganisms between the upper and lower airways. This can lead to lung infections, amounting to billions of dollars in annual direct treatment costs in the United States, depending on the etiologic agent [2,3]. Curcumin has been described as a photosensitizer (PS) that, activated at 450 nm, is efficient against planktonic bacteria [4] and biofilms [5]. At the same time, effects on microbial interactions are commonly detected in the upper res-piratory tract and should be considered for the treatment of adenoids [6]. We, therefore, propose in this study to optimize photodynamic therapy (PDT) conditions in vitro by simulating bacterial coinfection conditions in nasal cavities evaluated by the response surface method, where we can evaluate interactions of treatment variables. From this, the clinical case of the treatment of rhinosinusitis was carried out using PDT with nasal lighting. The absence of symptoms that characterize the disease was monitored and evaluated by the Kepler Meyer method. The study points out considerations that can be evaluated for the treatment to be a possibility of clinical indi-cation in the control of rhinosinusitis. (AU)

• FAPESP's process: 19/12694-3 - Treatment of pharyngotonsillitis with photodynamic action
• Grantee: Kate Cristina Blanco
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/09952-0 - Treatment of pharyngotonsillitis with photodynamic action: investigation of basic mechanisms
• Grantee: Kate Cristina Blanco
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor