| Full text | |
| Author(s): |
Rodrigues, Anderson Messias
;
Goncalves, Sarah Santos
;
de Carvalho, Jamile Ambrosio
;
Borba-Santos, Luana P.
;
Rozental, Sonia
;
de Camargo, Zoilo Pires
Total Authors: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF FUNGI; v. 8, n. 8, p. 32-pg., 2022-08-01. |
| Abstract | |
Sporotrichosis, a human and animal disease caused by Sporothrix species, is the most important implantation mycosis worldwide. Sporothrix taxonomy has improved in recent years, allowing important advances in diagnosis, epidemiology, and treatment. Molecular epidemiology reveals that S. brasiliensis remains highly prevalent during the cat-transmitted sporotrichosis outbreaks in South America and that the spread of S. brasiliensis occurs through founder effects. Sporothrix globosa and S. schenckii are cosmopolitan on the move, causing major sapronoses in Asia and the Americas, respectively. In this emerging scenario, one-health approaches are required to develop a creative, effective, and sustainable response to tackle the spread of sporotrichosis. In the 21st century, it has become vital to speciate Sporothrix, and PCR is the main pillar of molecular diagnosis, aiming at the detection of the pathogen DNA from clinical samples through multiplex assays, whose sensitivity reaches remarkably three copies of the target. The treatment of sporotrichosis can be challenging, especially after the emergence of resistance to azoles and polyenes. Alternative drugs arising from discoveries or repositioning have entered the radar of basic research over the last decade and point to several molecules with antifungal potential, especially the hydrazone derivatives with great in vitro and in vivo activities. There are many promising developments for the near future, and in this review, we discuss how these trends can be applied to the Sporothrix-sporotrichosis system to mitigate the advance of an emerging and re-emerging disease. (AU) | |
| FAPESP's process: | 17/27265-5 - Molecular epidemiology and genomic perspectives on the evolution and spread of emerging fungal pathogens |
| Grantee: | Anderson Messias Rodrigues |
| Support Opportunities: | Research Grants - Young Investigators Grants |