Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis

Author(s)

Kawashima-Vasconcelos, Marianna Y. ; Santana-Goncalves, Maynara ; Zanin-Silva, Djulio C. ; Malmegrim, Kelen C. R. ; Oliveira, Maria Carolina

• Document type: Journal article
• Source: FRONTIERS IN IMMUNOLOGY; v. 13, p. 16-pg., 2022-08-11.

Abstract

Systemic sclerosis (SSc) is a chronic autoimmune disease that includes fibrosis, diffuse vasculopathy, inflammation, and autoimmunity. Autologous hematopoietic stem cell transplantation (auto-HSCT) is considered for patients with severe and progressive SSc. In recent decades, knowledge about patient management and clinical outcomes after auto-HSCT has significantly improved. Mechanistic studies have contributed to increasing the comprehension of how profound and long-lasting are the modifications to the immune system induced by transplantation. This review revisits the immune monitoring studies after auto-HSCT for SSc patients and how they relate to clinical outcomes. This understanding is essential to further improve clinical applications of auto-HSCT and enhance patient outcomes. (AU)

• FAPESP's process: 17/09420-3 - Evaluation of the impact of hematopoietic stem cell transplantation on the vascular aspects of systemic sclerosis
• Grantee: Marianna Yumi Kawashima Vasconcelos
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC