Leukocyte metabolism in obese type 2 diabetic individuals associated with COVID-19 severity

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Lobato, Tiago Bertola ; Gennari-Felipe, Matheus ; Barbosa Pauferro, Janaina Ribeiro ; Correa, Ilana Souza ; Santos, Beatriz Ferreira ; Dias, Beatriz Belmiro ; de Oliveira Borges, Joao Carlos ; dos Santos, Camila Soares ; de Sousa Santos, Elvirah Samantha ; Leite de Araujo, Maria Janaina ; Ferreira, Liliane Araujo ; Pereira, Sara Araujo ; Afonso Serdan, Tamires Duarte ; Levada-Pires, Adriana Cristina ; Hatanaka, Elaine ; Borges, Leandro ; Cury-Boaventura, Maria Fernanda ; Ramirez Vinolo, Marco Aurelio ; Pithon-Curi, Tania Cristina ; Masi, Laureane Nunes ; Curi, Rui ; Hirabara, Sandro Massao ; Gorjao, Renata

• Document type: Journal article
• Source: FRONTIERS IN MICROBIOLOGY; v. 13, p. 18-pg., 2022-11-03.

Abstract

Recent studies show that the metabolic characteristics of different leukocytes, such as, lymphocytes, neutrophils, and macrophages, undergo changes both in the face of infection with SARS-CoV-2 and in obesity and type 2 diabetes mellitus (DM2) condition. Thus, the objective of this review is to establish a correlation between the metabolic changes caused in leukocytes in DM2 and obesity that may favor a worse prognosis during SARS-Cov-2 infection. Chronic inflammation and hyperglycemia, specific and usual characteristics of obesity and DM2, contributes for the SARS-CoV-2 replication and metabolic disturbances in different leukocytes, favoring the proinflammatory response of these cells. Thus, obesity and DM2 are important risk factors for pro-inflammatory response and metabolic dysregulation that can favor the occurrence of the cytokine storm, implicated in the severity and high mortality risk of the COVID-19 in these patients. (AU)

• FAPESP's process: 18/09868-7 - Cellular and molecular mechanisms of insulin resistance and inflammation in obese Wistar rats and lean Goto-Kakizaki rats: causes and associations with diet and physical exercise
• Grantee: Rui Curi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/07283-1 - Effects of leptin on lymphocyte differentiation and metabolism
• Grantee: Renata Gorjao
• Support Opportunities: Regular Research Grants