Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria

Author(s)

Roque-Borda, Cesar Augusto ; Da Silva, Patricia Bento ; Rodrigues, Mosar Correa ; Filippo, Leonardo Delello Di ; Duarte, Jonatas L. ; Chorilli, Marlus ; Vicente, Eduardo Festozo ; Garrido, Saulo Santesso ; Pavan, Fernando Rogenio

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 241, p. 18-pg., 2022-08-12.

Abstract

Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, the application of several AMPs to biological systems is hampered by their poor stability and lifetime, inactivating them completely. Therefore, nanotechnology plays an important role in the development of new AMP-based drugs, protecting and carrying the bioactive to the target. This is the first review article on the different reported nanosystems using AMPs against bacteria listed on the WHO priority list. The current shortage of information implies a nano -biotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect. (AU)

• FAPESP's process: 21/14603-5 - Drug discovery and design: antimicrobial peptide B1CTcu5 analogs promising against Mycobacterium tuberculosis
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 20/13497-4 - Search for the mechanism of action and therapeutic effect of new classes of drugs against Mycobacterium tuberculosis
• Grantee: Fernando Rogério Pavan
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/16573-3 - In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/25707-3 - Application of the antimicrobial peptide Ctx(Ile21)-Ha and its conjugates in different formulations as a nutritional additive in laying hens
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships in Brazil - Master