Advanced search
Start date

In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis

Grant number: 20/16573-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2021
Effective date (End): March 31, 2026
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Fernando Rogério Pavan
Grantee:Cesar Augusto Roque Borda
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):21/14603-5 - Drug discovery and design: antimicrobial peptide B1CTcu5 analogs promising against Mycobacterium tuberculosis, BE.EP.DR


The development of new molecules is the basis of Pharmaceutical Microbiology, mainly because bacteria rapidly develop resistance to various drugs, including first-line drugs. The use of antimicrobial peptides (AMPs) has been an interesting and current area of research because these molecules are not considered drugs and generally do not generate or generate low resistance. Tuberculosis (TB) is a communicable infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. According to the World Health Organization (WHO), this disease is one of the ten main causes of death in the world and the main one caused by a single infectious agent, above HIV/AIDS. The synthetic peptide B1CTcu5 has 21 amino acid residues and was originally isolated from the cutaneous secretion of Clinotarsus curtipes. This peptide showed a promising initial study against M. tuberculosis and low cytotoxicity. However, the oral administration of peptide drugs, the main route of administration of the drug, is hampered due to the instability of these molecules under severe pH conditions and the enzymatic degradability imposed by the upper portions of the gastrointestinal tract. The microencapsulation of active agents with retrograded starch (AR)/Pectin (P) mixtures is an important technological tool that allows the targeting of peptides in the colon, an organ of excellence for the absorption of biotherapeutic agents. This peptide encapsulates in specific colon microparticles and studies its potential against M. tuberculosis through its portfolio of in vitro and in vivo studies. (AU)

Articles published in Pesquisa para Inovação FAPESP about the scholarships:
Scientists use chitosan to develop more stable antioxidant microparticles for cosmetics 
News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DI FILIPPO, LEONARDO DELELLO; DUARTE, JONATAS LOBATO; ROQUE-BORDA, CESAR AUGUSTO; PAVAN, FERNANDO ROGERIO; MENEGUIN, ANDREIA BAGLIOTTI; CHORILLI, MARLUS; MELERO, ANA; GUILLOT, ANTONIO JOSE; SPAGNOL, CAROLINE MAGNANI; CORREA, MARCOS ANTONIO. In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide. LIFE-BASEL, v. 12, n. 7, p. 14-pg., . (19/25125-7, 15/19097-0, 16/20957-6, 15/02619-3, 20/16573-3)
ROQUE-BORDA, CESAR AUGUSTO; DA SILVA, PATRICIA BENTO; RODRIGUES, MOSAR CORREA; FILIPPO, LEONARDO DELELLO DI; DUARTE, JONATAS L.; CHORILLI, MARLUS; VICENTE, EDUARDO FESTOZO; GARRIDO, SAULO SANTESSO; PAVAN, FERNANDO ROGENIO. Pharmaceutical nanotechnology: Antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 241, p. 18-pg., . (21/14603-5, 20/13497-4, 20/16573-3, 18/25707-3)
DE SOUZA, GUILHERME DA COSTA; ROQUE-BORDA, CESAR AUGUSTO; PAVAN, FERNANDO R.. Beta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteria. Drug Development Research, v. 83, n. 7, p. 21-pg., . (21/14603-5, 20/13497-4, 20/16573-3)
ROQUE-BORDA, CESAR AUGUSTO; SARAIVA, MAURO DE MESQUITA SOUZA; JUNIOR, WAGNER DIAS MACEDO; MONTESINOS, JOSE CARLOS ESTANISLAO MARQUEZ; MENEGUIN, ANDREIA BAGLIOTTI; BORGES, ANNA BEATRIZ TOLEDO; JUNIOR, EDSON CRUSCA; GARRIDO, SAULO SANTESSO; ALMEIDA, ADRIANA MARIA DE; MARCHETTO, REINALDO; et al. Chitosan and HPMCAS double-coating as protective systems for alginate microparticles loaded with Ctx(Ile21)-Ha antimicrobial peptide to prevent intestinal infections. Biomaterials, v. 293, p. 15-pg., . (18/25707-3, 20/16573-3, 16/00446-7)
ROQUE-BORDA, CESAR AUGUSTO; SOUZA SARAIVA, MAURO DE MESQUITA; MONTE, DANIEL F. M.; RODRIGUES ALVES, LUCAS BOCCHINI; DE ALMEIDA, ADRIANA MARIA; FERREIRA, TAISA SANTIAGO; DE LIMA, TULIO SPINA; PEREIRA BENEVIDES, VALDINETE; CABRERA, JULIA MEMRAVA; CLAIRE, SUNIL; et al. HPMCAS-Coated Alginate Microparticles Loaded with Ctx(Ile(21))-Ha as a Promising Antimicrobial Agent against Salmonella Enteritidis in a Chicken Infection Model. ACS INFECTIOUS DISEASES, v. 8, n. 3, p. 10-pg., . (20/13497-4, 18/25707-3, 20/16573-3, 16/00446-7)
DI FILIPPO, LEONARDO DELELLO; DUARTE, JONATAS; FONSECA-SANTOS, BRUNO; TAVARES JUNIOR, ALBERTO GOMES; ARAUJO, VICTOR; ROQUE BORDA, CESAR AUGUSTO; VICENTE, EDUARDO FESTOZO; CHORILLI, MARLUS. Mucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases. Current Medicinal Chemistry, v. 29, n. 17, p. 32-pg., . (20/12622-0, 19/25125-7, 20/16573-3, 18/23416-1)
ROQUE-BORDA, CESAR AUGUSTO; DA SILVA, PATRICIA BENTO; RODRIGUES, MOSAR CORREA; AZEVEDO, RICARDO BENTES; DI FILIPPO, LEONARDO; DUARTE, JONATAS L.; CHORILLI, MARLUS; VICENTE, EDUARDO FESTOZO; PAVAN, FERNANDO ROGERIO. Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria. PHARMACEUTICS, v. 13, n. 6, . (20/16573-3, 18/25707-3, 20/13497-4)
ROQUE-BORDA, CESAR AUGUSTO; ANTUNES, BRUNA FERNANDES; BORGUES, ANNA BEATRIZ TOLEDO; PONTES, JANAINA TEIXEIRA COSTA DE; MENEGUIN, ANDREIA BAGLIOTTI; CHORILLI, MARLUS; TROVATTI, ELIANE; TEIXEIRA, SILVIO RAINHO; PAVAN, FERNANDO ROGERIO; VICENTE, EDUARDO FESTOZO. Conjugation of Ctx(Ile(21))-Ha Antimicrobial Peptides to Chitosan Ultrathin Films by N-Acetylcysteine Improves Peptide Physicochemical Properties and Enhances Biological Activity. ACS OMEGA, v. 7, n. 32, p. 10-pg., . (20/16573-3, 20/13497-4, 18/25707-3)
ROQUE-BORDA, CESAR AUGUSTO; PAVAN, FERNANDO ROGERIO; MENEGUIN, ANDREIA BAGLIOTTI. Pharmaceutical Biotechnology. LIFE-BASEL, v. 12, n. 8, p. 3-pg., . (20/16573-3, 20/13497-4, 16/00446-7, 18/25707-3)
COSTA DE PONTES, JANAINA TEIXEIRA; TOLEDO BORGES, ANNA BEATRIZ; AUGUSTO ROQUE-BORDA, CESAR; PAVAN, FERNANDO ROGERIO. Antimicrobial Peptides as an Alternative for the Eradication of Bacterial Biofilms of Multi-Drug Resistant Bacteria. PHARMACEUTICS, v. 14, n. 3, p. 20-pg., . (20/16573-3, 20/13497-4)
POLINARIO, GIULIA; PRIMO, LAURA MARIA DURAN GLERIANI; ROSA, MAIARA ALANE BARALDI CERQUETANI; DETT, FREDDY HUMBERTO MARIN; BARBUGLI, PAULA ABOUD; ROQUE-BORDA, CESAR AUGUSTO; PAVAN, FERNANDO ROGERIO. Antimicrobial peptides as drugs with double response against Mycobacterium tuberculosis coinfections in lung cancer. FRONTIERS IN MICROBIOLOGY, v. 14, p. 17-pg., . (22/09728-6, 20/16573-3, 20/13497-4, 21/14603-5)
ROQUE-BORDA, CESAR AUGUSTO; DE LIMA GUALQUE, MARCOS WILLIAM; DA FONSECA, FAULLER HENRIQUE; PAVAN, FERNANDO ROGERIO; SANTOS-FILHO, NORIVAL ALVES. Nanobiotechnology with Therapeutically Relevant Macromolecules from Animal Venoms: Venoms, Toxins, and Antimicrobial Peptides. PHARMACEUTICS, v. 14, n. 5, p. 21-pg., . (20/13497-4, 20/16573-3)

Please report errors in scientific publications list using this form.