Does chromatin function as a metabolite reservoir?

Author(s)

Nirello, Vinicius D. ; de Paula, Dieggo Rodrigues ; AraOjo, Nathalia V. P. ; Varga-Weisz, Patrick D.

• Document type: Journal article
• Source: TRENDS IN BIOCHEMICAL SCIENCES; v. 47, n. 9, p. 4-pg., 2022-08-11.

Abstract

Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acylcoenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs. (AU)

• FAPESP's process: 21/05269-4 - Identification of histone crotonylation specific chromatin remodeling mechanisms in intestinal cells
• Grantee: Nathália Vitória Pereira Araújo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/16113-5 - Chromatin dynamics in host-microbiome crosstalk in health and disease
• Grantee: Patrick Daniel Varga-Weisz
• Support Opportunities: Research Projects - SPEC Program
• FAPESP's process: 21/00398-0 - Crosstalk between microbiota and histone modifications in the healthy gut
• Grantee: Dieggo Rodrigues de Paula
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 21/00393-9 - Role of histone acylations in linking gene expression to cellular metabolism in the gut
• Grantee: Vinícius Dias Nirello
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)