Role of histone acylations in linking gene expression to cellular metabolism in the gut

• Grant number: 21/00393-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2021
• End date: February 28, 2026
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Patrick Daniel Varga-Weisz
• Grantee: Vinícius Dias Nirello
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 19/16113-5 - Chromatin dynamics in host-microbiome crosstalk in health and disease, AP.SPEC
• Associated scholarship(s): 23/06408-3 - Unravelling dynamics of microbiota-dependent gene expression and chromatin remodelling in intestinal epithelium and liver, BE.EP.DD

Abstract

Protein Posttranslational Modifications (PTMs) link to metabolic states through their dependence on precursor molecules such as ATP or acetyl-CoA. This is also true for PTMs of histones which are an important facet of gene regulation. The newly discovered range of histone acylations, such as crotonylation, adds a new layer of complexity to this molecular process. The nexus between histone modifications and metabolism may be particularly important in the intestinal epithelium. We will employ state-of-the-art approaches, including single cell transcriptome and chromatin analysis, to reveal how alternative histone acylations coordinate gene expression with metabolism in the intestinal epithelium. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NIRELLO, VINICIUS D.; DE PAULA, DIEGGO RODRIGUES; ARAOJO, NATHALIA V. P.; VARGA-WEISZ, PATRICK D.. Does chromatin function as a metabolite reservoir?. TRENDS IN BIOCHEMICAL SCIENCES, v. 47, n. 9, p. 4-pg., 2022-08-11. (21/05269-4, 19/16113-5, 21/00398-0, 21/00393-9)

CORREA, RENAN OLIVEIRA; CASTRO, POLLYANA RIBEIRO; FACHI, JOSE LUIS; NIRELLO, VINICIUS DIAS; EL-SAHHAR, SALMA; IMADA, SHINYA; PEREIRA, GABRIEL VASCONCELOS; PRAL, LAIS PASSARIELLO; PEREIRA ARAUJO, NATHALIA VITORIA; FERNANDES, MARIANE FONT; et al. Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium. MICROBIOME, v. 11, n. 1, p. 25-pg., 2023-04-26. (16/23142-3, 21/06572-2, 19/06372-3, 19/16113-5, 19/02640-3, 18/15313-8, 20/02919-5, 17/16280-3, 20/14071-0, 21/00393-9, 17/06577-9, 20/13689-0, 21/05269-4, 20/02312-3, 18/10165-0, 20/00311-0)