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Role of histone acylations in linking gene expression to cellular metabolism in the gut

Grant number: 21/00393-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): June 01, 2021
Effective date (End): February 28, 2025
Field of knowledge:Biological Sciences - Immunology - Immunogenetics
Principal researcher:Patrick Daniel Varga-Weisz
Grantee:Vinícius Dias Nirello
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:19/16113-5 - Chromatin dynamics in host-microbiome crosstalk in health and disease, AP.SPEC

Abstract

Protein Posttranslational Modifications (PTMs) link to metabolic states through their dependence on precursor molecules such as ATP or acetyl-CoA. This is also true for PTMs of histones which are an important facet of gene regulation. The newly discovered range of histone acylations, such as crotonylation, adds a new layer of complexity to this molecular process. The nexus between histone modifications and metabolism may be particularly important in the intestinal epithelium. We will employ state-of-the-art approaches, including single cell transcriptome and chromatin analysis, to reveal how alternative histone acylations coordinate gene expression with metabolism in the intestinal epithelium. (AU)

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