Role of histone acylations in linking gene expression to cellular metabolism in the gut

• Grant number: 21/00393-9
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): June 01, 2021
• Effective date (End): February 28, 2025
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal researcher: Patrick Daniel Varga-Weisz
• Grantee: Vinícius Dias Nirello
• Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 19/16113-5 - Chromatin dynamics in host-microbiome crosstalk in health and disease, AP.SPEC

Abstract

Protein Posttranslational Modifications (PTMs) link to metabolic states through their dependence on precursor molecules such as ATP or acetyl-CoA. This is also true for PTMs of histones which are an important facet of gene regulation. The newly discovered range of histone acylations, such as crotonylation, adds a new layer of complexity to this molecular process. The nexus between histone modifications and metabolism may be particularly important in the intestinal epithelium. We will employ state-of-the-art approaches, including single cell transcriptome and chromatin analysis, to reveal how alternative histone acylations coordinate gene expression with metabolism in the intestinal epithelium. (AU)