Abstract
How the microbiota communicates with the host and contributes to health is a key question for progress in this research field. Bacterial metabolites called short chain fatty acids (SCFAs), which are generated by fermentation of non-digestible carbohydrates, constitute a link between microbiota and host cells. Previous studies demonstrated that these metabolites regulate host metabolism and immunity. However, the molecular mechanisms are not totally defined. The aim of this project is to investigate this by examining 1) activation of the SCFA receptor FFAR2 (GPR43) and 2) modification of the pattern of histone acylations (mainly, acetylation and crotonylation) in neutrophils and intestinal epithelial cells (IECs) and their biological relevance in inflammatory models. For this, we will 1) characterize, using cell-specific knockout mice, the role of FFAR2 in neutrophil and IEC functions, and its participation in inflammasome activation and relevance during intestinal inflammation and; 2) investigate the effect of SCFAs on the pattern of histone acylation in intestinal epithelial cells and neutrophils and how this affects their transcriptional and effector responses during inflammation. With this, we will contribute to the understanding of the molecular mechanisms of microbial-host interaction and identification of new biomarkers and therapeutic targets for inflammatory diseases. (AU)
Scientific publications(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FACHI, J. L.;
PRAL, L. P.;
DOS SANTOS, J. A. C.;
CODO, A. C.;
DE OLIVEIRA, S.;
FELIPE, J. S.;
ZAMBOM, F. F. F.;
CAMARA, N. O. S.;
VIEIRA, P. M. M. M.;
COLONNA, M.;
VINOLO, M. A. R.
Hypoxia enhances ILC3 responses through HIF-1 alpha-dependent mechanism.
MUCOSAL IMMUNOLOGY,
JAN 2021.
Web of Science Citations: 0.
ROCHA, ANDREA LIVIA;
DE LIMA, TANES IMAMURA;
DE SOUZA, GERSON PROFETA;
CORREA, RENAN OLIVEIRA;
FERRUCCI, DANILO LOPES;
RODRIGUES, BRUNO;
LOPES-RAMOS, CAMILA;
NILSSON, DANIEL;
KNITTEL, THIAGO LEITE;
CASTRO, POLLYANA RIBEIRO;
FERNANDES, MARIANE FONT;
MARTINS, FLAVIANO DOS SANTOS;
PARMIGIANI, RAPHAEL BESSA;
SILVEIRA, LEONARDO REIS;
CARVALHO, HERNANDES F.;
AUWERX, JOHAN;
VINOLO, MARCO AURELIO R.;
BOUCHER, JEREMIE;
MORI, MARCELO A.
Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression.
SCIENCE ADVANCES,
v. 6,
n. 49
DEC 2020.
Web of Science Citations: 0.
SATO, FABIO TAKEO;
YAP, YU ANNE;
CRISMA, AMANDA RABELLO;
PORTOVEDO, MARIANA;
MURATA, GILSON MASAHIRO;
HIRABARA, SANDRO MASSAO;
RIBEIRO, WILLIAN RODRIGUES;
FERREIRA, CAROLINE MARCANTONIO;
CRUZ, MAYSA MARIANA;
BERTAGLIA PEREIRA, JOICE NAIARA;
PAYOLLA, TANYARA BALIANI;
SATO GUIMA, SUZANA EIKO;
THOMAS, ANDREW MALTEZ;
SETUBAL, JOAO CARLOS;
CARDOSO ALONSO-VALE, MARIA ISABEL;
SANTOS, MARINILCE FAGUNDES;
CURI, RUI;
MARINO, ELIANA;
VINOLO, MARCO A. R.
Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism.
CELLS,
v. 9,
n. 9
SEP 2020.
Web of Science Citations: 0.