Correlating drug prescriptions with prognosis in severe COVID-19: first step towards resource management

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Levin, Anna S. ; Freire, Maristela P. ; de Oliveira, Maura Salaroli ; Nastri, Ana Catharina S. ; Harima, Leila S. ; Perdigao-Neto, Lauro Vieira ; Magri, Marcello M. ; Fialkovitz, Gabriel ; Figueiredo, Pedro H. M. F. ; Siciliano, Rinaldo Focaccia ; Sabino, Ester C. ; Carlotti, Danilo P. N. ; Rodrigues, Davi Silva ; Nunes, Fatima L. S. ; Ferreira, Joao Eduardo ; Hcfmusp COVID-19 Study Grp

• Document type: Journal article
• Source: BMC MEDICAL INFORMATICS AND DECISION MAKING; v. 22, n. 1, p. 9-pg., 2022-09-21.

Abstract

Background Optimal COVID-19 management is still undefined. In this complicated scenario, the construction of a computational model capable of extracting information from electronic medical records, correlating signs, symptoms and medical prescriptions, could improve patient management/prognosis. Methods The aim of this study is to investigate the correlation between drug prescriptions and outcome in patients with COVID-19. We extracted data from 3674 medical records of hospitalized patients: drug prescriptions, outcome, and demographics. The outcome evaluated was hospital outcome. We applied correlation analysis using a Logistic Regression algorithm for machine learning with Lasso and Matthews correlation coefficient. Results We found correlations between drugs and patient outcomes (death/discharged alive). Anticoagulants, used very frequently during all phases of the disease, were associated with good prognosis only after the first week of symptoms. Antibiotics very frequently prescribed, especially early, were not correlated with outcome, suggesting that bacterial infections may not be important in determining prognosis. There were no differences between age groups. Conclusions In conclusion, we achieved an important result in the area of Artificial Intelligence, as we were able to establish a correlation between concrete variables in a real and extremely complex environment of clinical data from COVID-19. Our results are an initial and promising contribution in decision-making and real-time environments to support resource management and forecasting prognosis of patients with COVID-19. (AU)

• FAPESP's process: 20/12859-0 - Evolution of computational infrastructure for storage and retrieval scientific health data
• Grantee: Davi Silva Rodrigues
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 20/07205-0 - Evolution of computational infrastructure for storage and retrieval scientific health data
• Grantee: João Eduardo Ferreira
• Support Opportunities: Regular Research Grants