The inflammasomes: crosstalk between innate immunity and hematology

Author(s)

Dutra, Valeria de Freitas ; Cordeiro Leal, Vinicius Nunes ; Pontillo, Alessandra

• Document type: Journal article
• Source: Inflammation Research; v. 71, n. 12, p. 14-pg., 2022-10-20.

Abstract

Background The inflammasome is a cytosolic multi-protein complex responsible for the proteolytic maturation of pro-inflammatory cytokines IL-1ss and IL-18 and of gasdermin-D, which mediates membrane pore formation and the cytokines release, or eventually a lytic cell death known as pyroptosis. Inflammation has long been accepted as a key component of hematologic conditions, either oncological or benign diseases. Objectives This study aims to review the current knowledge about the contribution of inflammasome in hematologic diseases. We attempted to depict the participation of specific inflammasome receptors, and the possible cell-specific consequence of complex activation, as well as the use of anti-inflammasome therapies. Methods We performed a keyword-based search in public databases (Pubmed.gov, ClinicalTrials.gov.). Conclusion Different blood cells variably express inflammasome components. Considering the immunosuppression associated with both the disease and the treatment of some hematologic diseases, and a microenvironment that allows neoplastic cell proliferation, inflammasomes could be a link between innate immunity and disease progression, as well as an interesting therapeutic target. (AU)

• FAPESP's process: 20/15323-3 - Disregulation of inflammasome' activation in neutrophil and endothelium in response to SARS-Cov-2 and contribution to severe COVID-19
• Grantee: Vinícius Nunes Cordeiro Leal
• Support Opportunities: Scholarships in Brazil - Post-Doctoral