Lower paraoxonase 1 paraoxonase activity is associated with a worse prognosis in patients with non-ST-segment elevation myocardial infarction in long-term follow-up

Author(s)

Lacerda Leocadio, Paola Caroline ; Goulart, Alessandra Carvalho ; Santos, Itamar Souza ; Lotufo, Paulo Andrade ; Bensenor, Isabela Martins ; Alvarez-Leite, Jacqueline Isaura

• Document type: Journal article
• Source: Coronary Artery Disease; v. 33, n. 7, p. 8-pg., 2022-11-01.

Abstract

Background Acute coronary syndrome (ACS) is one of the main manifestations of coronary artery disease, with a higher prevalence and worst prognosis. Oxidative stress is important in atherosclerosis and ACS, and paraoxonase 1 (PON1) is directly related to reducing the effects of oxidative stress on lipoproteins. The present study evaluated the prognostic value of PON1 activity in patients with non-ST-segment elevation ACS [non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA)], included in the ERICO study. Methods PON1 paraoxonase activity was determined in serum samples from 485 patients collected on admission. The prognostic value in the follow-up of up to 5 years was evaluated according to cutoff points established by tertiles. Kaplan-Meier curves and Cox regression were used for the analysis of all-cause mortality and cardiovascular mortality. Results The sample consisted mainly of elderly patients with a high frequency of cardiovascular risk factors. At follow-up of up to 5 years, there were 126 deaths from all causes (80 deaths from CVD). The lowest tertile of PON1 paraoxonase activity was associated with a higher risk of death in patients with NSTEMI, but not in patients with UA. Conclusion PON1 paraoxonase activity has potential prognostic value in patients with NSTEMI. (AU)

• FAPESP's process: 12/14804-1 - Evaluation of prognostic factors associated to acute coronary syndrome at hospital admission and after 30 days in the study "Strategy of registry in acute coronary syndrome study" (ERICO)
• Grantee: Isabela Judith Martins Bensenor
• Support Opportunities: Regular Research Grants