Platelet aggregation and antiaggregation in coronary artery disease patients

• Grant number: 14/01021-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: September 01, 2016
• End date: August 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Carlos Nicolau
• Grantee: José Carlos Nicolau
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alexandre da Costa Pereira ; André Franci ; Bruno Guardieiro ; Carlos Eduardo Negrão ; Carlos Eduardo Rochitte ; Carlos José Dornas Gonçalves Barbosa ; Celia Maria Cassaro Strunz ; Elbio Antonio D'Amico ; Fernando Reis Menezes ; Flávia Bittar Britto Arantes ; Itamara Lucia Itagiba Neves ; José Eduardo Krieger ; Luciano Moreira Baracioli ; Marco Antonio Gutierrez ; Maria Urbana Pinto Brandão Rondon ; Paulo Roberto Rizzo Genestreti ; Raul Cavalcante Maranhao ; Remo Holanda de Mendonça Furtado ; Talia Falcão Dalçóquio ; Viviane Moreira de Lima ; Wilson Mathias Júnior
• Associated research grant(s): 20/04705-2 - Diagnostic and prognostic study of SARS-CoV-2 and Influenza virus infection, AP.R
• Associated scholarship(s): 17/26922-2 - The importance of platelet aggregability in different presentations of Coronary Artery Disease: from subclinical Atherosclerosis to Acute Coronary Syndromes, BP.PD; 18/02306-3 - Standardization of adenosine erythrocyte reuptake technique in patients on dual antiplatelet therapy in INCOR-HC laboratory INCOR-HC, BP.IC; 17/06012-1 - Comparison of platelet aggregation by VerifyNow Aspirin® and Multiplate ASPI® methods in coronary disease patients with Diabetes Mellitus, BP.IC; 16/21190-0 - Comparing intraoral bleeding time with platelet aggregability by the Multiplate ADP method in coronary artery disease patients undergoing tooth extraction, BP.IC; 16/23161-8 - Comparing platelet aggregation by VerifyNow P2Y12 and Multiplate ADP in coronary artery disease patients using dual platelet anti aggregation before and after assisted physical training, BP.IC

Abstract

The recent demonstration that high on-treatment platelet reactivity is a common phenomenon, and that these patients have a worse prognosis when undergoing coronary angioplasty, along with the development of new devices for assessing platelet aggregation, reliably and relatively simple, led to an exponential increase in the scientific interest on the subject. Considering just the PubMed database, there were only 358 publications in the 70', whereas in the past decade that number went up to 8,218. However, as often happens with emerging subjects, despite the large amount of knowledge produced, there is now a lot more questions than answers. The aim of this project is to contribute to a better understanding of the subject, seeking answers to a number of pathophysiological questions that today permeate the literature. Some questions that we intend to answer are: Is there any difference in platelet aggregability between patients with initial coronary artery disease diagnosed by multislice computed tomography and those with normal coronary arteries?; Does renal function have any influence on the antiplatelet potency of clopidogrel or ticagrelor?; Does glucose-lowering DPP4-inhibitors influence platelet aggregation in patients with acute coronary syndromes?; Can the evaluation of platelet aggregation lead to better use of hemostatic techniques in dental extractions?; What results would be obtained when comparing prasugrel and ticagrelor in the same population, and what is the correlation between them and adenosine plasma concentration?; Exercise training influences platelet aggregability and sympathetic activity in patients with acute myocardial infarction? (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALSOSO, ROCIO; DALCOQUIO, TALIA F.; FURTADO, REMO H. M.; FRANCI, ANDRE; BARBOSA, CARLOS J. D. G.; GENESTRETI, PAULO R. R.; STRUNZ, CELIA M. C.; LIMA, VIVIANE; BARACIOLI, LUCIANO M.; GIUGLIANO, ROBERT P.; et al. Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease. ADVANCES IN THERAPY, SEP 2020. (14/01021-4, 14/03742-0, 17/26922-2)

GUARDIEIRO, BRUNO; SANTOS-PAUL, MARCELA ALVES; FURTADO, REMO HOLANDA DE MENDONCA; DALCOQUIO, TALIA; SALSOSO, ROCIO; NEVES, ITAMARA LUCIA ITAGIBA; NEVES, RICARDO SIMOES; CAVALHEIRO FILHO, CYRILLO; BARACIOLI, LUCIANO MOREIRA; NICOLAU, JOSE CARLO. COMPARISON BETWEEN TWO DIFFERENT LOCAL HEMOSTATIC METHODS FOR DENTAL EXTRACTIONS IN PATIENTS ON DUAL ANTIPLATELET THERAPY: A WITHIN-PERSON, SINGLE-BLIND, RANDOMIZED STUDY. JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE, v. 23, n. 3, p. 11-pg., 2023-09-01. (14/01021-4)

RIZZO GENESTRETI, PAULO R.; FURTADO, REMO H. M.; SALSOSO, ROCIO; DALCOQUIO, TALIA F.; FRANCI, ANDRE; MENEZES, FERNANDO R.; CAPORRINO, CESAR; FERRARI, ALINE G.; NAKASHIMA, CARLOS A. K.; SCANAVINI FILHO, MARCO A.; et al. Effects of DPP4 Inhibitor in Platelet Reactivity and Other Cardiac Risk Markers in Patients with Type 2 Diabetes and Acute Myocardial Infarction. JOURNAL OF CLINICAL MEDICINE, v. 11, n. 19, p. 15-pg., 2022-10-01. (14/01021-4)

DALCOQUIO, TALIA FALCAO; DOS SANTOS, MAYARA ALVES; ALVES, LEANDRO SILVA; BRITO ARANTES, FLAVIA BITTAR; FERREIRA-SANTOS, LARISSA; PINTO BRANDAO RONDON, MARIA URBANA; FURTADO, REMO HOLANDA M.; FERRARI, ALINE GEHLEN; GENESTRETI RIZZO, PAULO ROBERTO; SALSOSO, ROCIO; et al. Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial. PLATELETS, v. N/A, p. 9-pg., 2022-11-16. (17/24605-0, 14/01021-4)

SALSOSO, ROCIO; DALCOQUIO, TALIA F.; FURTADO, REMO H. M.; FRANCI, ANDRE; BARBOSA, CARLOS J. D. G.; GENESTRETI, PAULO R. R.; STRUNZ, CELIA M. C.; LIMA, VIVIANE; BARACIOLI, LUCIANO M.; GIUGLIANO, ROBERT P.; et al. Relation of High Lipoprotein (a) Concentrations to Platelet Reactivity in Individuals with and Without Coronary Artery Disease. ADVANCES IN THERAPY, v. 37, n. 11, p. 17-pg., 2020-09-05. (14/03742-0, 17/26922-2, 14/01021-4)