Comparing platelet aggregation by VerifyNow P2Y12 and Multiplate ADP in coronary artery disease patients using dual platelet anti aggregation before and after assisted physical training

• Grant number: 16/23161-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2016
• Effective date (End): November 30, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Carlos Nicolau
• Grantee: Fernanda Reali de Oliveira
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 14/01021-4 - Platelet aggregation and antiaggregation in coronary artery disease patients, AP.TEM

Abstract

Clinical trials in healthy subjects demonstrate that moderate intensity training reduces adhesiveness and platelet agregability at rest and in response to intense physical exercise. Although recent evidence has shown a significant reduction in the recurrence of cardiovascular events with the use of new and more potent antiplatelet agents in coronary patients, its percentage is not negligible, which reinforces the need for additional measures to further decrease these rates. The assessment of platelet aggregation in patients with post-AMI who underwent assisted physical training may clarify the role of exercise in modulating it. (AU)