Comparison of platelet aggregation by VerifyNow Aspirin® and Multiplate ASPI® methods in coronary disease patients with Diabetes Mellitus

• Grant number: 17/06012-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2017
• Effective date (End): April 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: José Carlos Nicolau
• Grantee: Matheus de Almeida Leite Petroni
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 14/01021-4 - Platelet aggregation and antiaggregation in coronary artery disease patients, AP.TEM

Abstract

The association between diabetes and platelet reactivity is well known and a recent publication has shown that the recurrence of thrombotic events in the month following acute coronary syndrome treated with percutaneous coronary intervention is four times higher in the diabetic than in the non-diabetic population. The effect of oral hypoglycemic treatment on the acute phase of myocardial infarction and its possible pleiotropic effects related to platelet aggregation could significantly change the prognosis of these patients. In this context, evaluation of platelet aggregability has great relevance and clinical applicability, but the ideal method is still not well established in the literature, being the same targets of several clinical trials and consensus recently published. (AU)