Embryo-fetal safety evaluation of ondansetron in rats

Author(s)

Reis, Ana Carolina Casali ; Jorge, Barbara Campos ; Moreira, Suyane da Silva ; Stein, Julia ; Perdao, Carolina Barizan ; Manoel, Beatriz de Matos ; Arena, Arielle Cristina

• Document type: Journal article
• Source: BIRTH DEFECTS RESEARCH; v. N/A, p. 9-pg., 2023-02-03.

Abstract

Background: Ondansetron is a 5HT3 receptor antagonist, used to mitigate the effects of nausea and vomiting after chemotherapy or surgery. Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has been the main drug used during this period.Methods: To evaluate the effects of ondansetron on the embryo-fetal development, which are still very contradictory, pregnant rats were exposed to therapeutic doses of ondansetron (1.7 or 2.5 mg/kg) daily, from gestational day (GD) 6 to 15.Results: No clinical signs of toxicity were observed in dams during the treatment. Although the hematobiochemical parameters were similar among the groups, histological changes, as well as a reduction in the weight of kidney were found in the treated dams. After fetal examination, no visceral and skeletal abnormalities were observed in treated fetuses.Conclusion: In conclusion, therapeutic doses of ondansetron have low terato-genic potential in rats. These data provide important information about the drug safety during pregnancy. (AU)

• FAPESP's process: 20/08745-9 - Influence of in utero exposure to ondansetron: teratogenic effects and late repercussions on reproductive and behavioral parameters in male rats
• Grantee: Ana Carolina Casali Reis
• Support Opportunities: Scholarships in Brazil - Master