| Full text | |
| Author(s): Show less - |
Oliveira Alves, Monica Ghislaine
;
Miguel, Natalia da Silva
;
Panisello Ferreira, Camila Cristina
;
Alvarenga, Elis Ribeiro
;
Tonon, Bruna Manzanares
;
de Barros, Patricia Pimentel
;
Lima Carta, Celina Faig
;
Nogueira Paschoal, Maria Beatriz
;
de Sales Chagas, Jose Francisco
;
Bandeira, Celso Muller
;
Nunes, Fabio Daumas
;
Almeida, Janete Dias
Total Authors: 12
|
| Document type: | Journal article |
| Source: | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 130, n. 3, p. 8-pg., 2020-09-01. |
| Abstract | |
Objective. The aim of this study was to evaluate the expression of DNA repair genes in cases of oral squamous cell carcinoma (OSCC). Study Design. Expression of the MLH1, MSH2, MLH3, ATM, MRE11A, XRCC1, and PMS2 genes was evaluated by reverse transcription-quantitative polymerase chain reaction in the OSCC group (32 patients) and the control group (15 patients). The groups were compared by using the Mann-Whitney test, with Bonferroni correction. Associations between gene expression levels and clinical data were explored by using Pearson's and Spearman's correlation coefficients, with P value less than .05 indicating a significant difference. Results. The MLH1, MSH2, MLH3, ATM, MRE11A, XRCC1, and PMS2 genes were downregulated in the OSCC group compared with the control group, with significant values for MLH1 (P < .0001); MSH2 (P = .038); MLH3 (P < .0001); ATM (P < .0001); MRE11A (P < .0001); XRCC1 (P = .0004); and PMS2 (P = .008). Analysis of the correlation between gene expression and clinical data only revealed a significant negative correlation between age and expression of the PMS2 gene. Conclusions. Expression of the DNA repair genes MLH1, MSH2, MLH3, ATM, MRE11 AMRE1 JA, XRCC1, and PMS2 was reduced in OSCC. (AU) | |
| FAPESP's process: | 16/08633-0 - TOBACCO SMOKING: FROM MOLECULAR ASPECTS TO SMOKER APPROACHES |
| Grantee: | Janete Dias Almeida |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/23179-7 - Study of MLH3 and ATM genes expression in oral squamous cell carcinoma |
| Grantee: | Camila Cristina Panisello Ferreira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/21227-4 - MLH1 and MLH2 gene expression in buccal squamous cell carcinoma |
| Grantee: | Natália da Silva Miguel |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |