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Influence of polymorphisms in genes related to DNA repair system in the susceptibility to squamous cell carcinoma of the oropharynx

Grant number: 12/18623-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): August 31, 2013
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Carmen Silvia Passos Lima
Grantee:Erika Stocco dos Santos
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The squamous cell carcinoma (SCC) of the oropharynx (OR) is a serious global health problem. It is well known that individuals with habits of smoking and drinking alcohol for many years are more likely to develop SCCOR. There are genes that play a role in the regulation pathways that control cellular responses to DNA damage caused by reactive oxygen species formed by the combustion of tobacco and ingestion of alcohol. In addition, these genes are polymorphic in humans. However, little is known roles of the polymorphisms OGG1 c.977C> G, APEX1 c.444T> G, and XRCC1 c.580C> T, c.839G> A, c.1196A> G and c.-77C > T, related to DNA base excision repair, in the occurrence of SCCOR, as well as its clinical manifestations. Based on these, these were the objectives of this study. Will be assessed 200 patients with SCC of the OR and 200 controls matched to patients by age, sex and skin color, in the Oncology Clinic Ambulatory of the Clinical Hospital of UNICAMP. Clinical information will be obtained from patient charts by the researcher responsible for the study. The genotyping will be performed by polymerase chain reaction and restriction enzyme digestion. The statistical significance of differences between groups will be calculated using the exact probability test or Fisher's chi-square test and multiple logistic regression. The determinations of risk of occurrence of SCCOR, that patients and controls underwent, will be obtained through the odds ratios (ORs) and calculated assuming a confidence interval of 95%. We believe the results of this study may contribute to a better understanding of the etiology and pathophysiology of SCCOR, to identify groups of individuals at high risk for the disease, which receive merit special attention for prevention and early diagnosis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS COSTA, ERICKA FRANCISLAINE; SANTOS, ERIKA STOCCO; LIUTTI, VITOR TEIXEIRA; LEAL, FREDERICO; ANTUNES SANTOS, VIVIAN CASTRO; RINCK-JUNIOR, JOSE AUGUSTO; VIVIANE MARIANO, FERNANDA; MALHEIROS COUTINHO-CAMILLO, CLAUDIA; ALTEMANI, ALBINA; PASSOS LIMA, CARMEN SILVIA; et al. Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, v. 142, n. 9, p. 1917-1926, . (12/18623-1)

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