Strain-, Sex-, and Time-Dependent Antidepressant-like Effects of Cannabidiol

Author(s)

Silote, Gabriela P. ; Gatto, Michelle C. ; Eskelund, Amanda ; Guimaraes, Francisco S. ; Wegener, Gregers ; Joca, Samia R. L.

• Document type: Journal article
• Source: PHARMACEUTICALS; v. 14, n. 12, p. 19-pg., 2021-12-01.

Abstract

Cannabidiol (CBD) is a non-intoxicating compound extracted from Cannabis sativa, showing antidepressant-like effects in different rodent models. However, inconsistent results have been described depending on the species and the strain used to assess depressive-like behavior. Moreover, only a few studies investigated the effect of CBD in female rodents. Therefore, we aimed to (i) investigate the effects of CBD in two different strains of mice (Swiss and C57BL/6) and a rat model of depression based on selective breeding (Flinders Sensitive and Resistant Lines, FSL and FRL) subjected to tests predictive of antidepressant-like effects and (ii) investigate the influence of sex in the effects of CBD in both mice and rats. CBD induced an antidepressant-like effect in male Swiss but not in female Swiss or C57BL/6 mice in the tail suspension test (TST). In male FSL rats, CBD produced an antidepressant-like effect 1 h post injection. However, in female FSL, CBD induced a bimodal effect, increasing the immobility time at 1 h and decreasing it at 2 h. In conclusion, strain, sex, and administration time affect CBD's behavioral response to rodents exposed to tests predictive of antidepressant effects. (AU)

• FAPESP's process: 17/26815-1 - Investigation of the involvement of the BDNF-TrkB pathway in the mechanism of action of the rapid and sustained antidepressant-like effect induced by canabidiol
• Grantee: Gabriela Pandini Silote
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 18/12119-6 - Investigation of the molecular mechanisms involved in the rapid and sustained antidepressant-like effects induced by Cannabidiol
• Grantee: Gabriela Pandini Silote
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate