Anacardic Acid Derivatives Affect the in Vitro Reactions of Photosynthesis

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Author(s):	de Carvalho, Ana Calheiros ; Severino, Richele Priscila ; Abubakar, Mustapha Ngaski ; Machado, Fernando Cassas Salles ; Bassicheto, Milena Costa ; Di Gioia Silva, Giordanno ; Vieira, Paulo Cezar ; Veiga, Thiago A. M. Total Authors: 8
Document type:	Journal article
Source:	CHEMISTRY & BIODIVERSITY; v. 19, n. 6, p. 9-pg., 2022-05-27.
Abstract
The dichloromethane extract of the cashew nuts from Anacardium occidentale was fractionated by rotation locular countercurrent chromatography aimed at discovering metabolites that could be useful as new models for photosynthesis inhibitors. The chemical fractionation afforded a complex mixture of anacardic acids, which upon catalytic hydrogenation yielded anacardic acid (1). Methylation of 1 via reaction with diazomethane afforded an ester 2. Both compounds were evaluated using polarographic approaches and fluorescence studies of chlorophyll a (ChL a). The in vitro assays informed the decision for the classification of 1 and 2 as Hill reaction inhibitors. Besides that, 1 inhibited the donor side of the PSII, while 2 acted as an energy transfer inhibitor. Therefore, this study is important for the development of herbicides. (AU)

FAPESP's process:	18/04095-0 - Analytical Approaches for Discovering Unknown Cytotoxic Compounds from Plants
Grantee:	Thiago André Moura Veiga
Support Opportunities:	Regular Research Grants