| Full text | |
| Author(s): Show less - |
Goncalves, Milena Giulia
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Ferreira, Matthew Thomas
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Mendoza Lopez, Rossana Veronica
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Ferreira, Silvaneide
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Sirak, Bradley
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Baggio, Maria Luiza
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Lazcano-Ponce, Eduardo
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Nyitray, Alan G.
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Giuliano, Anna R.
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Villa, Luisa L.
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Sichero, Laura
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HIM Study Grp
Total Authors: 12
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| Document type: | Journal article |
| Source: | Journal of Clinical Virology; v. 149, p. 7-pg., 2022-03-22. |
| Abstract | |
Background: HPV-16 causes approximately 90% of anal canal (AC) cancers worldwide. This study aimed to evaluate the prevalence and persistence of HPV-16 genetic variants in the AC of men from three different countries (Brazil, Mexico and United States) and to further identify sociodemographic and behavioral factors associated with these infections.& nbsp;Methods: Participants from the multinational prospective HPV Infection in Men (HIM) Study who had at least one HPV-16 positive AC swab were included. Characterization into HPV-16 genetic variants was successfully performed by PCR-sequencing in 95.6% (217/227) samples and these were classified into HPV-16 lineages and sublineages.& nbsp;Results: We observed higher prevalence of lineage A variants, mainly from A1 sublineage, in all countries. Non-A lineage variants were mostly detected in men from Brazil, where higher diversity of sublineage variants was detected during follow-up. Compare to men detected with Non-A HPV-16 lineage variants, men infected with lineage A reported a higher lifetime number of female sexual partners. Finally, a significantly higher prevalence of Non-A lineage variants was observed among men who have sex with men (MSM) with a transient HPV-16 AC infection (p = 0.033), but no significant differences regarding variants lineages and persistence status were observed when stratified by country, self-reported ethnicity or age.& nbsp;Conclusions: Our data extend previous reports which indicate that globally HPV-16 variants are unevenly distributed, and contribute further to studies of the natural history of AC HPV infections in men. (AU) | |
| FAPESP's process: | 08/57889-1 - Institute of Science and Technology to study Diseases Associated with Papillomavirus |
| Grantee: | Luisa Lina Villa |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/23211-8 - Impact of genetic variants of HPV on persistence of infection and risk of disease: an epidemiological and functional approach |
| Grantee: | Laura Cristina Sichero Vettorazzo |
| Support Opportunities: | Research Projects - Thematic Grants |