Subthalamic low beta bursts differ in Parkinson's disease phenotypes

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Neto, Arnaldo Fim ; de Luccas, Julia Baldi ; Bianqueti, Bruno Leonardo ; da Silva, Luiz Ricardo ; Almeida, Tiago Paggi ; Takahata, Andre Kazuo ; Teixeira, Manoel Jacobsen ; Figueiredo, Eberval Gadelha ; Nasuto, Slawomir J. ; Guimaraes Rocha, Maria Sheila ; Soriano, Diogo Coutinho ; Godinho, Fabio

• Document type: Journal article
• Source: CLINICAL NEUROPHYSIOLOGY; v. 140, p. 14-pg., 2022-08-01.

Abstract

lObjective: Parkinson's disease (PD) patients may be categorized into tremor-dominant (TD) and postural-instability and gait disorder (PIGD) motor phenotypes, but the dynamical aspects of subthalamic nucleus local field potentials (STN-LFP) and the neural correlates of this phenotypical classification remain unclear.Methods: 35 STN-LFP (20 PIGD and 15 TD) were investigated through continuous wavelet transform and machine-learning-based methods. The beta oscillation - the main band associated with motor impair-ment in PD - dynamics was characterized through beta burst parameters across phenotypes and burst intervals under specific proposed criteria for optimal burst threshold definition.Results: Low-frequency (13-22 Hz) beta burst probability was the best predictor for PD phenotypes (75% accuracy). PIGD patients presented higher average burst duration (p = 0.018), while TD patients exhibited higher burst probability (p = 0.014). Categorization into shorter and longer than 400 ms bursts led to sig-nificant interaction between burst length categories and the phenotypes (p < 0.050) as revealed by mixed-effects models. Long burst durations and short bursts probability positively correlated, respec-tively, with rigidity-bradykinesia (p = 0.029) and tremor (p = 0.038) scores.Conclusions: Subthalamic low-frequency beta bursts differed between TD and PIGD phenotypes and cor-related with motor symptoms. (AU)

• FAPESP's process: 18/14285-0 - Spectral differences of local field potentials recorded in bilateral subthalamic nuclei of patients with Parkinson's Disease
• Grantee: Julia Baldi de Luccas
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/09512-0 - Nonlinear dynamic functional connectivity analysis via recurrence quantification and its application to brain computer-interfaces
• Grantee: Diogo Coutinho Soriano
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 17/00319-8 - Atrial substrate identification in patients with chronic atrial fibrillation using multivariate statistical models and multiple attributes from atrial electrograms
• Grantee: Tiago Paggi de Almeida
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/14283-8 - Spectral characteristics of local field potentials recorded in subthalamic nucleus in patients with Parkinson Disease
• Grantee: Bruno Leonardo Bianqueti
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 18/02251-4 - Characterizing persistent atrial fibrillation dynamics using computational models and recurrence quantification analysis - towards novel biomarkers for guiding therapy
• Grantee: Tiago Paggi de Almeida
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor